Chapter title |
Two-Pulse Endosomal Stimulation of Receptor Tyrosine Kinases Induces Cell Proliferation
|
---|---|
Chapter number | 9 |
Book title |
ErbB Receptor Signaling
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-7219-7_9 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7218-0, 978-1-4939-7219-7
|
Authors |
Steven Pennock, Sukhmani Billing, Zhixiang Wang, Yi Wang |
Abstract |
Signals transduced from ligand-activated receptor tyrosine kinases (RTKs) lead to a diverse array of biological outcomes, such as cell proliferation. Strict regulation of RTK activity is therefore necessary to prevent aberrancies in cell signaling that can lead to diseases such as cancer. RTKs are activated at the plasma membrane (PM) upon ligand binding. Contrary to the initial belief, RTK activity does not terminate immediately following endocytosis, instead RTKs remain active while being trafficked in endosomes. Here we describe a two-pulse endosomal stimulation approach which can specifically activate endosome-accumulated EGFR and drive cell proliferation. |
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