Reproducibility of native myocardial T1 mapping in the assessment of Fabry disease and its role in early detection of cardiac involvement by cardiovascular magnetic resonance
Published in
Critical Reviews in Diagnostic Imaging, December 2014
Silvia Pica, Daniel M Sado, Viviana Maestrini, Marianna Fontana, Steven K White, Thomas Treibel, Gabriella Captur, Sarah Anderson, Stefan K Piechnik, Matthew D Robson, Robin H Lachmann, Elaine Murphy, Atul Mehta, Derralyn Hughes, Peter Kellman, Perry M Elliott, Anna S Herrey, James C Moon
Abstract
Cardiovascular magnetic resonance (CMR) derived native myocardial T1 is decreased in patients with Fabry disease even before left ventricular hypertrophy (LVH) occurs and may be the first non-invasive measure of myocyte sphingolipid storage. The relationship of native T1 lowering prior to hypertrophy and other candidate early phenotype markers are unknown. Furthermore, the reproducibility of T1 mapping has never been assessed in Fabry disease.
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