Title |
Synthesis, antimicrobial and in vitro antitumor activities of a series of 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives
|
---|---|
Published in |
Drug Design, Development and Therapy, July 2015
|
DOI | 10.2147/dddt.s86054 |
Pubmed ID | |
Authors |
Nizar M Mhaidat, Mousa Al-Smadi, Fouad Al-Momani, Karem H Alzoubi, Iman Mansi, Qosay Al-Balas |
Abstract |
Three derivatives of substituted 1,2,3-thia- or 1,2,3-selenadiazole (4a-c) were prepared and characterized by different chemical techniques. These compounds were evaluated for their antimicrobial and antitumor activities. Compounds 4a (propenoxide derivative), 4b (carbaldehyde derivative), and 4c (benzene derivative) were active against the yeast-like fungi Candida albicans. Compound 4a was active against gram-negative Escherichia coli, and compound 4c was active against the gram-positive Staphylococcus aureus. For the antitumor activity, both compounds 4b and 4c were active against all tested tumor cell lines, namely, SW480, HCT116, C32, MV3, HMT3522, and MCF-7. The activity of compound 4c was greater than that of compound 4b and more than that of the reference antitumor 5-flourouracil against the SW480, HCT116, and MCF-7 tumor cell lines. In conclusion, a number of the prepared 1,2,3-thia- or 1,2,3-selenadiazole compounds showed promising antifungal, antibacterial, and in vitro antitumor activities. Further investigations are required to explore the mechanism by which active compound are inducing their cytotoxicity. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 3 | 18% |
Professor | 2 | 12% |
Student > Ph. D. Student | 2 | 12% |
Other | 1 | 6% |
Student > Bachelor | 1 | 6% |
Other | 2 | 12% |
Unknown | 6 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 5 | 29% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 12% |
Biochemistry, Genetics and Molecular Biology | 1 | 6% |
Medicine and Dentistry | 1 | 6% |
Agricultural and Biological Sciences | 1 | 6% |
Other | 0 | 0% |
Unknown | 7 | 41% |