Title |
Physiology of Hyperuricemia and Urate-Lowering Treatments
|
---|---|
Published in |
Frontiers in Medicine, May 2018
|
DOI | 10.3389/fmed.2018.00160 |
Pubmed ID | |
Authors |
Caroline L. Benn, Pinky Dua, Rachel Gurrell, Peter Loudon, Andrew Pike, R. Ian Storer, Ciara Vangjeli |
Abstract |
Gout is the most common form of inflammatory arthritis and is a multifactorial disease typically characterized by hyperuricemia and monosodium urate crystal deposition predominantly in, but not limited to, the joints and the urinary tract. The prevalence of gout and hyperuricemia has increased in developed countries over the past two decades and research into the area has become progressively more active. We review the current field of knowledge with emphasis on active areas of hyperuricemia research including the underlying physiology, genetics and epidemiology, with a focus on studies which suggest association of hyperuricemia with common comorbidities including cardiovascular disease, renal insufficiency, metabolic syndrome and diabetes. Finally, we discuss current therapies and emerging drug discovery efforts aimed at delivering an optimized clinical treatment strategy. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 20% |
United States | 1 | 20% |
Singapore | 1 | 20% |
Switzerland | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 341 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 50 | 15% |
Student > Master | 36 | 11% |
Student > Postgraduate | 22 | 6% |
Student > Ph. D. Student | 21 | 6% |
Other | 18 | 5% |
Other | 58 | 17% |
Unknown | 136 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 81 | 24% |
Pharmacology, Toxicology and Pharmaceutical Science | 25 | 7% |
Nursing and Health Professions | 21 | 6% |
Biochemistry, Genetics and Molecular Biology | 19 | 6% |
Chemistry | 17 | 5% |
Other | 35 | 10% |
Unknown | 143 | 42% |