The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
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| Title |
Fc glycans of therapeutic antibodies as critical quality attributes
|
|---|---|
| Published in |
Glycobiology, August 2015
|
| DOI | 10.1093/glycob/cwv065 |
| Pubmed ID | |
| Authors |
Dietmar Reusch, Max L Tejada |
| Abstract |
Critical quality attributes (CQA) are physical, chemical, biological or microbiological properties or characteristics that must be within an appropriate limit, range, or distribution to ensure the desired product quality, safety, and efficacy. For monoclonal antibody therapeutics that rely on Fc-mediated effector function for their clinical activity, the terminal sugars of Fc glycans have been shown to be critical for safety or efficacy. Different glycosylation variants have also been shown to influence the pharmacodynamic and pharmacokinetic behavior while other Fc glycan structural elements may be involved in adverse immune reactions. This review focuses on the role of Fc glycans as CQAs. Fc glycan information from published literature is summarized and evaluated for impact on patient safety, immunogenicity, bioactivity and pharmacodynamics/pharmacokinetics. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 16% |
| United States | 2 | 11% |
| Unknown | 14 | 74% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 53% |
| Scientists | 7 | 37% |
| Practitioners (doctors, other healthcare professionals) | 1 | 5% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 514 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 2 | <1% |
| Italy | 1 | <1% |
| Switzerland | 1 | <1% |
| Belgium | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 508 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 121 | 24% |
| Student > Ph. D. Student | 86 | 17% |
| Student > Master | 48 | 9% |
| Other | 43 | 8% |
| Student > Bachelor | 42 | 8% |
| Other | 45 | 9% |
| Unknown | 129 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 120 | 23% |
| Agricultural and Biological Sciences | 75 | 15% |
| Chemistry | 43 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 39 | 8% |
| Chemical Engineering | 21 | 4% |
| Other | 71 | 14% |
| Unknown | 145 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 April 2024.
All research outputs
#1,356,760
of 26,549,961 outputs
Outputs from Glycobiology
#22
of 2,111 outputs
Outputs of similar age
#16,532
of 276,657 outputs
Outputs of similar age from Glycobiology
#1
of 31 outputs
Altmetric has tracked 26,549,961 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,111 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,657 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.