Chapter title |
Computational Prediction of microRNA Targets
|
---|---|
Chapter number | 12 |
Book title |
microRNA: Basic Science
|
Published in |
Advances in experimental medicine and biology, January 2015
|
DOI | 10.1007/978-3-319-22380-3_12 |
Pubmed ID | |
Book ISBNs |
978-3-31-922379-7, 978-3-31-922380-3
|
Authors |
Laganà, Alessandro, Alessandro Laganà |
Abstract |
Computational prediction of microRNA (miRNA) targets is a fundamental step towards the characterization of miRNA function and the understanding of their role in disease. A single miRNA can regulate hundreds of different gene transcripts through partial sequence complementarity and a single gene may be regulated by several miRNAs acting cooperatively. The remarkable advances made in recent years have allowed the identification of key features for functional miRNA binding sites. A plethora of prediction tools are now available, but their accuracies remain rather poor, as miRNA target recognition has revealed itself to be a very complex and dynamic mechanism, still only partially understood.In this chapter, the principles of miRNA target prediction in animals are presented, together with the most up-to-date and effective computational approaches and tools available. |
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