@Parsifaler Thank you! Can you please research how the extreme ROS of Covid relates to the G6PD enzyme - crucial for each cell to determine the rate of glucose used to produce protective NADPH vs to produce inflammatory oxidative burst? https://t.co/snE1St
Last article why I'm mentioning G6PD in this https://t.co/DUVIxvhsX6
@criprights I have read that, and has me quite concerned it plays a part of the long covid I have been dealing with. Waiting for an appointment with a hematologist to find out more. From another paper I’ve read: 4/? https://t.co/ixHdIWChbO
@PutrinoLab This paper has an interesting analysis regarding the critical role of NADPH in neutralizing oxidative stress-& NADPH can be inadequate due to either mitochondria impairment or low G6PD enzyme (genetic or acquired) https://t.co/snE1St7yiL
@Parsifaler Does it also seem maybe the spike protein induces a pro-oxidant response & the individual’s attempt & ability to neutralize it with GSH/NADPH/G6PD or not at various phases may result in cascades? https://t.co/NFZIuYOhjP
@cryptaltd G6PD hypothesis https://t.co/LgLRZ5ckLu
@DrChristianWin1 Solche lokalen Besonderheiten können überlagert werden. Bluthochdruck, Übergewicht, Diabetes wirken im Zellstoffwechsel ähnlich wie G6PD Insuffizienzen. In Summe verstärken sie sich, einzeln fallen sie nicht so stark ins Gewicht. https://
« Both G6PD deficiency and SARS-CoV-2 compromise the antioxidant system through the same pathways rendering G6PD deficiency the Achilles' heel for COVID-19 » https://t.co/NHC1fbOq20
RT @TerriFalbo: @JoydeepGrover @VirusesImmunity Okay. But please also consider the role g6pd enzyme plays & the relationship of its level t…
Yep! Keep those reseach papers coming. 💜/ Centrality of #G6PD in #COVID19: The Biochemical Rationale & Clinical Implications by Y.Buinitskaya 🇪🇪, R.Gurinovich 🇪🇪, C.G.Wlodaver 🇺🇸, & S.Kastsiuchenka 🇦🇪; Front. Med., 22 October 2020 https://t.co/E5VD
RT @thirokazu_uc: #COVID19 における #G6PD 欠損症の中心性 https://t.co/VwuBkvw1Sd #ビタミンD がG6PDとして知られる遺伝子と結合し、その活性とグルコース-6-リン酸デヒドロゲナーゼと呼ばれる酵素の産生を増加させるこ…
@HAHassaballaMD True. In particular, maybe those who don’t have any *known* underlying conditions should be checked for G6PDd - & some conditions can cause acquired low G6PD & G6PDd under conditions of chronic oxidative stress may exacerbate diabet
@FailedToComply @lisa99491828 @EdoajoEric ALL the ‘comorbidities’ are also more likely to have low G6PD enzyme (& VitD- which links w/G6PD for optimal immune function) - so it’s a tragedy that focus hasn’t been in this direction https://t.co/snE1St7yiL
@shih_ru @PLOSPathogens What would it take to get done? For over a year MDs & biochemists have been asking for this research on SARS-CoV-2 & G6PDd cells — as well as G6PDd in correlation studies - but 95% are undiagnosed + can be acquired https://
@AngelaReiersen @farid__jalali @srrezaie @cameronks @ICS_updates @yourICM @JAMA_current @NEJM @TheLancet @WesElyMD @iceman_ex @stkirsch Here’s a biochemical explanation of G6PD deficiency (acquired & genetic) & relation to immunity & Covid symp
@NeilFlochMD @txsalth2o @CDCgov Ok. I will have to look at actual %- but even so - it still misses the WHY? & that obesity & metabolic diseases can lower cellular G6PD levels - resulting in less defense against oxidative infections https://t.co/snE
@ChelleStenn @tmprowell @Cleavon_MD @mtmdphd @CMichaelGibson @TomVargheseJr @Aiims1742 @EricTopol @uche_blackstock @meganranney @DrLeanaWen @VirusesImmunity @MackayIM Agree. Also likely with the virus itself (like coronavirus 229E proven mild to ‘normal’ G
@awgaffney It leaves out the fact that HCoV229E was proven mild to ‘normal’ G6PD cells, while virulent vs low G6PD & biochemical reasons why low G6PD can cause all the array of bad reactions - including mast cell activation https://t.co/snE1St7yiL
@jenbrea @BRayfield18 @DrRupaMarya @Cleavon_MD Also - the extreme oxidative stress of COVID19 likely depletes G6PD from adrenals & brain (areas of highest concentration) & ⬇️NADPH - so ⬇️T3 production —> hypometabolism https://t.co/snE1St7yiL
@bluelightdiet @NCancellable @dockaurG G6PD is also more present in these populations. https://t.co/nfQ7TSk6ZL Vitamin D binds with G6 PD to make it more active, which is great. Except that these folks are very D deficient!
@MollyJongFast & everyone keeps missing the connection of bad Covid reactions & bad reactions to HCQ on top of it with low G6PD/VitD link (& inability to overcome the oxidative stress of the combo) https://t.co/snE1St7yiL
@wendylee21742 In addition, low G6PD can be acquired in metabolic diseases https://t.co/snE1St7yiL
@HiljaGebest @SoSowemimo Low G6PD also in those groups-so important to look at combo of G6PD & VitD role in innate immune system https://t.co/snE1St7yiL
@EbonyJHilton_MD @HealthyBRHD @VDHgov @uvahealthnews Socioeconomic factors (including racism) are extremely important - but should NOT be used as an excuse to continue to ignore G6PDd & it’s difference w/our immune system when faced w/oxidant triggers
@davidefiri @VirusesImmunity @Emma_S_Chambers Thank you! I’m curious about how G6PDH deficiency was determined. Was genetic testing used? If so- was testing only for Mediterranean variant? (& why do you think there were no heterozygous females?) Here’
@pash22 @barttels2 @haiderwarraich @DrAoifeMolloy @drtimwilson @CatherineThomp8 @janewilcock @DanVickMD @medpagetoday @NIHRresearch @PeterHorby @statnews @VPrasadMDMPH @stevennovella Also use biochemical info & testing of patients to measure T3, GGT, G
@InCytometry @ThisIsTheWorl18 @gruffdavies @_JJacobs @Coronavirusgoo1 @MattHancock https://t.co/nfQ7TSk6ZL And guess what? Vit D up regulates the G6 PD gene.
RT @TerriFalbo: @independentabe @GeorgeFareed2 @RMConservative Inability to overcome extreme oxidative stress on the human cell —> less cel…
@independentabe @GeorgeFareed2 @RMConservative Inability to overcome extreme oxidative stress on the human cell —> less cell membrane protection & less NOX2 for macrophage defense https://t.co/snE1St7yiL
@KirinDave @EmilyGorcenski @Alex_Autistic @DogStarGirl @digitaldraco It could have everything to do with Covid19 & many- if not all- deaths might have been prevented if this wasn’t ignored https://t.co/snE1St7yiL
@devisridhar Do you know if G6PD deficiency is considered as a vulnerable condition re COVID in the UK? This paper suggests it perhaps should be, esp. given B117 variant associated with higher viral load in blood? https://t.co/PpQvFSfdh3 Thanks for all t
@DrBrittaniJ It’s not beyond the realm of possibility that *proper* research (designed to help people) on G6PD enzyme could have prevented most - if not all - deaths during this pandemic. Low G6PD can be acquired as well as genetic. https://t.co/snE1St7yiL
@usatodaysports @Cleavon_MD Yet- still the connection w/low G6PD is ignored - a travesty. G6PD is depleted by Covid’s oxidative stress- known in past https://t.co/snE1St7yiL
@mojo12469 Here is a biochemical explanation about why reactions to COVID19 causes severe reactions when G6PD is low https://t.co/snE1St7yiL
@CindyFitch1 Everything is a range - so even people w/‘normal’ G6PD genetics could start out on the low end- then pregnancy lowers it in 65% of women (temporary) & low VitD causes it to be less active - so important for everyone! https://t.co/snE1St7yi
@YourBoYJc1 @samhusseini @nashville_brook Vitamin D links with G6PD to make it more active. G6PD is needed to overcome Covid19’s extreme oxidative stress & is the major director of the innate immune system of each cell. https://t.co/snE1St7yiL
RT @TerriFalbo: @thomcdonald This is the best biochemical explanation I have seen for what Covid does in the body. Not sure how we can get…
RT @TerriFalbo: @Marxslovechild @bigblackjacobin Here is a biochemical explanation as to why low G6PD is linked to severe COVID19 reactions…
@nickbrne @Cadmarch @BorisJohnson HCQ is dangerous for people with endogenous glutathione deficiency (G6PD deficiency https://t.co/nfQ7TSk6ZL). It is useless when not used early, in small doses and along with zinc. Guess what? Vit. D up regulates G6PD. It
@GidMK @DavidLWindt True, if deficiency is measured solely in terms of serum level. My main concern is lack of research on link of low G6PD w/severe Covid reactions (& VitD in relation to THAT) https://t.co/snE1St7yiL
@cereus_context @MSS_Writing @timkmak Still seems severe reactions are mostly w/people likely to have low G6PD- as 2008 study proved about coronavirus 229E.(& VitD links to G6PD) Seems many lives could have been saved if this was focus of research &
@UREssien @venessawong @amichelson18 @mgodoyh @KatherineJWu @edyong209 @kat__stafford @Carolynyjohnson @MeghnaWBUR Health Equity & national conversation needs to expand to include ending racism in research & treatment that ignores G6PDd (& link
@LEastsound @UREssien @ProfLWiley @businessinsider @BuzzFeedNews @CDCgov G6PDd protects us from malaria & some other pathogens & cancers - but can be a DISadvantage w/oxidative chemicals, meds, & viruses & we need proper attention to that!
@awgaffney Here’s an explanation of how low G6PD (genetic or acquired) accounts for aberrant immune response, including cytokine storm. &VitD links to G6PD - so when low affect each other https://t.co/snE1St7yiL
@Marxslovechild @bigblackjacobin Here is a biochemical explanation as to why low G6PD is linked to severe COVID19 reactions https://t.co/snE1St7yiL
@Sue_Levitan @foundmyfitness Much evidence that low G6PD (genetic or acquired) likely for revere reactions to COVID19 & Vitamin D links w/G6PD to make it more active to fight Covid19’s extreme ROS https://t.co/snE1St7yiL
@RephreshedMind @KpopStrong @Covid19Critical @drbeen_medical Biochemical rationale for link between severe Covid reactions & low G6PD (genetic & acquired) https://t.co/snE1St7yiL
@charles90979675 @Cleavon_MD @realangsiegel Her death is heartbreaking & could have been prevented by stopping spread thru masks — as well as proper focus of research & treatment on role of low G6PD - lower in 65% of pregnant women & more likel
@DrRobDavidson @Cleavon_MD @ratemyskyperoom @DrPhillipsMD Hero vs people who refuse to wear masks (& research negligence of role of low G6PD & VitD in severe Covid reactions - as well as ‘co-morbidities’) - treatment implications could save lives &
@TheyCallMeAfra @MollyJongFast G6PD is major player in our innate immune system & VitD links with it. Both are needed to overcome Covid’s extreme oxidative stress (& both are related to all the other ‘co-morbidities) https://t.co/snE1St7yiL
@pjputh According to this, high GGT & low T3 indicates NADPH depletion. (Could be from G6PD deficiency - acquired or genetic -95% genetic are undiagnosed & likely 100% of acquired) https://t.co/snE1St7yiL
@Smashalley2534 @CyntHarp @Cleavon_MD Here’s a peer-reviewed paper on the biochemical explanation for link of severe Covid reactions to low G6PD (genetic or acquired) https://t.co/snE1St7yiL
@alan2102z I think it's both. We know that HCQ is very dangerous in people with genetic deficiency(G6PD) https://t.co/nfQ7TSk6ZL But it can also be due to medication. Many of these medications also deplete vit. D, so it's is a vicious cycle (Vit D up regu
@birdgirl1001 @DrEricDing Deaths are due to a combo of spread thru not wearing masks + lack of focus of research & treatment on low G6PD (& VitD & NAC to alleviate severe reactions) https://t.co/snE1St7yiL
@LSince1987 @CRYSTAL212114 @NYC_essentialSW @DrEricDing @GSAEmily @CAPAction All threats to children deserve attention- especially if checking them for G6PDd & treating with VitD & NAC could prevent suffering & death. https://t.co/snE1St7yiL
@ERIC_Yale @voguemagazine Disparities caused by racism in treatment & socio-economics need to be addressed. Hoping also racism in research that ignores role of G6PD will end so lives can be saved https://t.co/snE1St7yiL
@AutismDrMom @MaaloufMD Low G6PD can be genetic or acquired. G6PD needed for NADPH & GSH to overcome Covid’s extreme oxidative stress. Lives can be saved if this were not ignored! https://t.co/snE1St7yiL
RT @TerriFalbo: @drnic1 @dianaberrent @bmj_latest Low T3 with high GGT indicates low NADPH per this paper (which also describes the importa…
@drnic1 @dianaberrent @bmj_latest Low T3 with high GGT indicates low NADPH per this paper (which also describes the important functions of NADPH) https://t.co/snE1Stp9aj
@louayonhiscouch @raoult_didier Déficit en G6PD phénomènes thrombotiques et fibrose pulmonaire. https://t.co/rz5TfYt1eW https://t.co/9engCVn9zT https://t.co/eipxZuTsu2 https://t.co/1nO6jlsXQv https://t.co/rz5TfYt1eW https://t.co/z0KbJq0vRa https://t.co/Bo
@LeeWardMarch @gagabloggerette @tonypnz @DrEricDing Deeper shows G6PD enzyme is guiding force of innate immune system of each cell- setting% of energy towards oxidant destruction vs % NADPH production & COVID19 depletes, & VitD activates & NAC
@vivek_murthy @JudyWoodruff @NewsHour Wonderful ideas on lessening spread. Hoping new admin can also influence research & treatment focus that could save many lives - like not ignoring the evidence linking severe Covid reactions to low G6PD https://t.c
@HAHassaballaMD @BeingWellpub Biochemical explanation of Covid19 & G6PD link https://t.co/snE1St7yiL
@Pi60527493 @bmaja405 @Karl_Lauterbach Vit. D verhindert Zytokinstürme: https://t.co/WdANNnZRPm Und Vit. D macht auch das G6PD Gen (welches in schweren Covid Verläufen defizitär ist, und zu oxidative Stress führt), aktiv. Und vieles mehr. Aber es macht Ph
@FelicityEnders @DrLaPrincess @egaly Biochemical rationale for G6PD centrality in severe COVID19 https://t.co/snE1St7yiL
@TaisonBell @RickABright Hoping the Task Force will seriously consider all the evidence of the centrality of G6DP depletion in COVID19 https://t.co/snE1St7yiL
RT @TerriFalbo: I know the Pfizer trial is being touted - but until then, need to have better treatment to prevent Covid deaths. Trials of…
@ResusOne @JoeBiden @Transition46 In 2013 my mom suddenly had all the severe reactions people today have w/COVID19. Found out all were due to depletion of G6PD, NADPH, & GSH - & there have been biochemical explanations about all this for years. htt
@ClarenceMarten2 @Vhtempopro @FatEmperor @GrahamNeary Look at all the talk about G6PD deficiency and glutathione depletion in Covid outcomes, for example this article: https://t.co/nfQ7TSk6ZL What they don't mention is that adequate Vit. D levels increase
@raul22 @DrEricDing Biochemical explanation of why low G6PD causes distorted immune reaction to viruses that cause extreme ROS - like COVID19 https://t.co/snE1St7yiL
I know the Pfizer trial is being touted - but until then, need to have better treatment to prevent Covid deaths. Trials of VitD & NAC have been excellent separately. Both help G6PD. Biochemical explanation here https://t.co/snE1St7yiL
RT @HiljaGebest: @DrEmilyGrossman Guess what, Vit. D deficiency exacerbates congenital G6PD deficiency, which accompanies insulin resistanc…
@DrEmilyGrossman Guess what, Vit. D deficiency exacerbates congenital G6PD deficiency, which accompanies insulin resistance and hypertension, grouped together as the metabolic syndrome, as well as advancing age. Vit. D binds with G6PD to make it more acti
@egaly tho low G6PD (genetic or acquired) could be major reason for severe reactions w/COVID19 https://t.co/snE1St7yiL
#COVID19 における #G6PD 欠損症の中心性 https://t.co/VwuBkvw1Sd #ビタミンD がG6PDとして知られる遺伝子と結合し、その活性とグルコース-6-リン酸デヒドロゲナーゼと呼ばれる酵素の産生を増加させることを発見。#VitaminD
RT @zzz_as_zzz: G6PD欠損症の遺伝子を持っている場合や、肥満から来る高血圧などの場合、マクロファージ経由のTNF-αによってインスリン抵抗性が出てG6PD不足になり、ROSによる酸化ストレスが上昇し新型コロナウイルス感染でも重症化する、という興味深い論文。 h…
RT @TerriFalbo: @butchpa @Ellysiumfields @axios Interesting that she mentions she had malaria & it was “a walk in the park” because G6PD de…
RT @HiljaGebest: Centrality of G6PD deficiency in COVID-19: https://t.co/nfQ7TSk6ZL Guess what? Vit. D binds with G6PD to make it more acti…
My bet: a G6PD deficiency is worsened by low vitamin D and leading to a vicious cycle. Let's start from the beginning: G6PD enzyme defect is the result of a Single-Nucleotide Polymorphism (SNP)affecting the gene responsible for expressing the G6PD enzyme
RT @TerriFalbo: @DrEricDing More reason to stop ignoring low G6PD as reason for severe reactions to COVID19 & treatment implications to sav…
How prevalent do you think G6PD deficiency is? @DrEricDing @TerriFalbo
@reclaimuc @DrCSWilliam Stop ignoring the role of low G6PD in severe Covid reactions so the slaughter can stop! https://t.co/snE1St7yiL
@BBCLucyAdams So sorry. ❤️Interesting that you mentioned having a mild case of malaria- because G6PD deficiency is an advantage w/malaria but DISadvantage with extreme oxidative viruses like COVID19 https://t.co/snE1St7yiL
@butchpa @Ellysiumfields @axios Interesting that she mentions she had malaria & it was “a walk in the park” because G6PD deficiency is an advantage w/malaria - but a DISadvantage w/ extreme oxidative chemicals, drugs & viruses like COVID19 https://
RT @TerriFalbo: @aerotycoon @axios @PattyArquette Lives could be saved NOW if attention were paid to the multitude of evidence that low G6P…
@aerotycoon @axios @PattyArquette Lives could be saved NOW if attention were paid to the multitude of evidence that low G6PD is the reason for severe reactions to COVID19! https://t.co/snE1St7yiL
@DrEricDing More reason to stop ignoring low G6PD as reason for severe reactions to COVID19 & treatment implications to save lives https://t.co/snE1Stp9aj
@AliNouriPhD @DrEricDing Hoping science & public policy will acknowledge the multitude of evidence that low G6PD (& NADPH) play in severe Covid reactions & treatment applications to save lives https://t.co/snE1St7yiL
@j_g_allen @VirusesImmunity But also kids tend to have higher levels of G6PD - even those with genetic G6PD deficiency (for which kids w/no *known* health issues who died or suffered a lot from COVID19 should be checked) https://t.co/snE1St7yiL
@EveShapiro4 @DrBrittaniJ Biochemical explanation for why worst Covid reactions are from low G6PD (genetic or acquired) & why Vitamin D & NAC help https://t.co/snE1St7yiL
Centrality of G6PD deficiency in COVID-19: https://t.co/nfQ7TSk6ZL Guess what? Vit. D binds with G6PD to make it more active. https://t.co/1HXOS4Uoq4
@AnnetteTimony @chrislhayes For friend in hospital - see if docs will check if CGT & T3 are low -Signs of depleted g6pd, GSH & NADPH. If so- NAC & active VitD help. Here is biochemical explanation https://t.co/snE1St7yiL
@bruce_y_lee @nic_fisher @bethlinas @Vaccinologist @InfectiousDz @DrLindaMD @NeilFlochMD @HansaBhargavaMD @somedocs @alvie_barr Please stop ignoring Covid19’s g6pd depletion - so deaths & suffering can end https://t.co/snE1St7yiL
@LeeAnnKindness @askdrfatima @drard @ConscienHealth Black Panthers championed G6PD awareness & screening. Racism ignores. Research & treatment focus to make up for depleted g6pd during COVID19 could save many lives https://t.co/snE1St7yiL