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Biomimetic Scaffold with Aligned Microporosity Designed for Dentin Regeneration

Overview of attention for article published in Frontiers in Bioengineering and Biotechnology, June 2016
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Title
Biomimetic Scaffold with Aligned Microporosity Designed for Dentin Regeneration
Published in
Frontiers in Bioengineering and Biotechnology, June 2016
DOI 10.3389/fbioe.2016.00048
Pubmed ID
Authors

Silvia Panseri, Monica Montesi, Samuele Maria Dozio, Elisa Savini, Anna Tampieri, Monica Sandri

Abstract

Tooth loss is a common result of a variety of oral diseases due to physiological causes, trauma, genetic disorders, and aging and can lead to physical and mental suffering that markedly lowers the individual's quality of life. Tooth is a complex organ that is composed of mineralized tissues and soft connective tissues. Dentin is the most voluminous tissue of the tooth and its formation (dentinogenesis) is a highly regulated process displaying several similarities with osteogenesis. In this study, gelatin, thermally denatured collagen, was used as a promising low-cost material to develop scaffolds for hard tissue engineering. We synthetized dentin-like scaffolds using gelatin biomineralized with magnesium-doped hydroxyapatite and blended it with alginate. With a controlled freeze-drying process and alginate cross-linking, it is possible to obtain scaffolds with microscopic aligned channels suitable for tissue engineering. 3D cell culture with mesenchymal stem cells showed the promising properties of the new scaffolds for tooth regeneration. In detail, the chemical-physical features of the scaffolds, mimicking those of natural tissue, facilitate the cell adhesion, and the porosity is suitable for long-term cell colonization and fine cell-material interactions.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 19%
Student > Master 9 17%
Student > Bachelor 6 12%
Student > Doctoral Student 3 6%
Researcher 3 6%
Other 6 12%
Unknown 15 29%
Readers by discipline Count As %
Medicine and Dentistry 14 27%
Biochemistry, Genetics and Molecular Biology 11 21%
Materials Science 4 8%
Chemistry 3 6%
Neuroscience 1 2%
Other 3 6%
Unknown 16 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2016.
All research outputs
#13,780,559
of 22,876,619 outputs
Outputs from Frontiers in Bioengineering and Biotechnology
#1,752
of 6,626 outputs
Outputs of similar age
#182,567
of 340,472 outputs
Outputs of similar age from Frontiers in Bioengineering and Biotechnology
#11
of 34 outputs
Altmetric has tracked 22,876,619 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,626 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,472 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.