Title |
Model-Based PAT for Quality Management in Pharmaceuticals Freeze-Drying: State of the Art
|
---|---|
Published in |
Frontiers in Bioengineering and Biotechnology, February 2017
|
DOI | 10.3389/fbioe.2017.00005 |
Pubmed ID | |
Authors |
Davide Fissore |
Abstract |
Model-based process analytical technologies can be used for the in-line control and optimization of a pharmaceuticals freeze-drying process, as well as for the off-line design of the process, i.e., the identification of the optimal operating conditions. This paper aims at presenting the state of the art in this field, focusing, particularly, on three groups of systems, namely, those based on the temperature measurement (i.e., the soft sensor), on the chamber pressure measurement (i.e., the systems based on the test of pressure rise and of pressure decrease), and on the sublimation flux estimate (i.e., the tunable diode laser absorption spectroscopy and the valveless monitoring system). The application of these systems for in-line process optimization (e.g., using a model predictive control algorithm) and to get a true quality by design (e.g., through the off-line calculation of the design space of the process) is presented and discussed. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 6 | 26% |
Student > Ph. D. Student | 4 | 17% |
Other | 2 | 9% |
Student > Doctoral Student | 2 | 9% |
Researcher | 2 | 9% |
Other | 3 | 13% |
Unknown | 4 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 22% |
Biochemistry, Genetics and Molecular Biology | 3 | 13% |
Chemistry | 3 | 13% |
Engineering | 2 | 9% |
Business, Management and Accounting | 1 | 4% |
Other | 2 | 9% |
Unknown | 7 | 30% |