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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Engineering Muscle Networks in 3D Gelatin Methacryloyl Hydrogels: Influence of Mechanical Stiffness and Geometrical Confinement
|
|---|---|
| Published in |
Frontiers in Bioengineering and Biotechnology, April 2017
|
| DOI | 10.3389/fbioe.2017.00022 |
| Pubmed ID | |
| Authors |
Marco Costantini, Stefano Testa, Ersilia Fornetti, Andrea Barbetta, Marcella Trombetta, Stefano Maria Cannata, Cesare Gargioli, Alberto Rainer |
| Abstract |
In this work, the influence of mechanical stiffness and geometrical confinement on the 3D culture of myoblast-laden gelatin methacryloyl (GelMA) photo-crosslinkable hydrogels was evaluated in terms of in vitro myogenesis. We formulated a set of cell-laden GelMA hydrogels with a compressive modulus in the range 1 ÷ 17 kPa, obtained by varying GelMA concentration and degree of cross-linking. C2C12 myoblasts were chosen as the cell model to investigate the supportiveness of different GelMA hydrogels toward myotube formation up to 2 weeks. Results showed that the hydrogels with a stiffness in the range 1 ÷ 3 kPa provided enhanced support to C2C12 differentiation in terms of myotube number, rate of formation, and space distribution. Finally, we studied the influence of geometrical confinement on myotube orientation by confining cells within thin hydrogel slabs having different cross sections: (i) 2,000 μm × 2,000 μm, (ii) 1,000 μm × 1,000 μm, and (iii) 500 μm × 500 μm. The obtained results showed that by reducing the cross section, i.e., by increasing the level of confinement-myotubes were more closely packed and formed aligned myostructures that better mimicked the native morphology of skeletal muscle. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 141 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 141 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 36 | 26% |
| Student > Master | 25 | 18% |
| Researcher | 10 | 7% |
| Student > Bachelor | 9 | 6% |
| Student > Doctoral Student | 8 | 6% |
| Other | 15 | 11% |
| Unknown | 38 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 33 | 23% |
| Biochemistry, Genetics and Molecular Biology | 25 | 18% |
| Materials Science | 6 | 4% |
| Agricultural and Biological Sciences | 5 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Other | 22 | 16% |
| Unknown | 46 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 April 2017.
All research outputs
#18,540,642
of 22,962,258 outputs
Outputs from Frontiers in Bioengineering and Biotechnology
#3,421
of 6,685 outputs
Outputs of similar age
#235,759
of 309,929 outputs
Outputs of similar age from Frontiers in Bioengineering and Biotechnology
#17
of 24 outputs
Altmetric has tracked 22,962,258 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,685 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 309,929 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.