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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Microenvironmental Regulation of Chondrocyte Plasticity in Endochondral Repair—A New Frontier for Developmental Engineering
|
|---|---|
| Published in |
Frontiers in Bioengineering and Biotechnology, May 2018
|
| DOI | 10.3389/fbioe.2018.00058 |
| Pubmed ID | |
| Authors |
Sarah A. Wong, Kevin O. Rivera, Theodore Miclau, Eben Alsberg, Ralph S. Marcucio, Chelsea S. Bahney |
| Abstract |
The majority of fractures heal through the process of endochondral ossification, in which a cartilage intermediate forms between the fractured bone ends and is gradually replaced with bone. Recent studies have provided genetic evidence demonstrating that a significant portion of callus chondrocytes transform into osteoblasts that derive the new bone. This evidence has opened a new field of research aimed at identifying the regulatory mechanisms that govern chondrocyte transformation in the hope of developing improved fracture therapies. In this article, we review known and candidate molecular pathways that may stimulate chondrocyte-to-osteoblast transformation during endochondral fracture repair. We also examine additional extrinsic factors that may play a role in modulating chondrocyte and osteoblast fate during fracture healing such as angiogenesis and mineralization of the extracellular matrix. Taken together the mechanisms reviewed here demonstrate the promising potential of using developmental engineering to design therapeutic approaches that activate endogenous healing pathways to stimulate fracture repair. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 39% |
| Australia | 1 | 4% |
| Germany | 1 | 4% |
| United Kingdom | 1 | 4% |
| Unknown | 11 | 48% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 65% |
| Scientists | 7 | 30% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 51 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 24% |
| Student > Master | 9 | 18% |
| Researcher | 5 | 10% |
| Student > Bachelor | 4 | 8% |
| Student > Doctoral Student | 3 | 6% |
| Other | 6 | 12% |
| Unknown | 12 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 16% |
| Agricultural and Biological Sciences | 6 | 12% |
| Medicine and Dentistry | 6 | 12% |
| Engineering | 6 | 12% |
| Veterinary Science and Veterinary Medicine | 2 | 4% |
| Other | 9 | 18% |
| Unknown | 14 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 June 2018.
All research outputs
#2,531,163
of 25,301,208 outputs
Outputs from Frontiers in Bioengineering and Biotechnology
#308
of 8,395 outputs
Outputs of similar age
#50,427
of 334,022 outputs
Outputs of similar age from Frontiers in Bioengineering and Biotechnology
#13
of 55 outputs
Altmetric has tracked 25,301,208 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,395 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,022 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.