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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Osteoblast Derived Exosomes Alleviate Radiation- Induced Hematopoietic Injury
|
|---|---|
| Published in |
Frontiers in Bioengineering and Biotechnology, April 2022
|
| DOI | 10.3389/fbioe.2022.850303 |
| Pubmed ID | |
| Authors |
Jianqi Xue, Ruikai Du, Shukuan Ling, Jinping Song, Xinxin Yuan, Caizhi Liu, Weijia Sun, Yuheng Li, Guohui Zhong, Yinbo Wang, Guodong Yuan, Xiaoyan Jin, Zizhong Liu, Dingsheng Zhao, Youyou Li, Wenjuan Xing, Yuanyuan Fan, Zifan Liu, Junjie Pan, Zhen Zhen, Yunzhang Zhao, Qinna Yang, Jianwei Li, Yan-Zhong Chang, Yingxian Li |
| Abstract |
As hematopoietic stem cells can differentiate into all hematopoietic lineages, mitigating the damage to hematopoietic stem cells is important for recovery from overdose radiation injury. Cells in bone marrow microenvironment are essential for hematopoietic stem cells maintenance and protection, and many of the paracrine mediators have been discovered in shaping hematopoietic function. Several recent reports support exosomes as effective regulators of hematopoietic stem cells, but the role of osteoblast derived exosomes in hematopoietic stem cells protection is less understood. Here, we investigated that osteoblast derived exosomes could alleviate radiation damage to hematopoietic stem cells. We show that intravenous injection of osteoblast derived exosomes promoted WBC, lymphocyte, monocyte and hematopoietic stem cells recovery after irradiation significantly. By sequencing osteoblast derived exosomes derived miRNAs and verified in vitro, we identified miR-21 is involved in hematopoietic stem cells protection via targeting PDCD4. Collectively, our data demonstrate that osteoblast derived exosomes derived miR-21 is a resultful regulator to radio-protection of hematopoietic stem cells and provide a new strategy for reducing radiation induced hematopoietic injury. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 5 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 1 | 20% |
| Professor > Associate Professor | 1 | 20% |
| Unknown | 3 | 60% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemical Engineering | 1 | 20% |
| Unknown | 4 | 80% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 July 2022.
All research outputs
#15,226,000
of 24,171,511 outputs
Outputs from Frontiers in Bioengineering and Biotechnology
#2,132
of 7,644 outputs
Outputs of similar age
#219,545
of 430,118 outputs
Outputs of similar age from Frontiers in Bioengineering and Biotechnology
#133
of 594 outputs
Altmetric has tracked 24,171,511 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,644 research outputs from this source. They receive a mean Attention Score of 3.6. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 430,118 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 594 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.