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Assembly and Turnover of Caveolae: What Do We Really Know?

Overview of attention for article published in Frontiers in Cell and Developmental Biology, June 2016
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Title
Assembly and Turnover of Caveolae: What Do We Really Know?
Published in
Frontiers in Cell and Developmental Biology, June 2016
DOI 10.3389/fcell.2016.00068
Pubmed ID
Authors

Bing Han, Courtney A. Copeland, Ajit Tiwari, Anne K. Kenworthy

Abstract

In addition to containing highly dynamic nanoscale domains, the plasma membranes of many cell types are decorated with caveolae, flask-shaped domains enriched in the structural protein caveolin-1 (Cav1). The importance of caveolae in numerous cellular functions and processes has become well-recognized, and recent years have seen dramatic advances in our understanding of how caveolae assemble and the mechanisms control the turnover of Cav1. At the same time, work from our lab and others have revealed that commonly utilized strategies such as overexpression and tagging of Cav1 have unexpectedly complex consequences on the trafficking and fate of Cav1. Here, we discuss the implications of these findings for current models of caveolae biogenesis and Cav1 turnover. In addition, we discuss how disease-associated mutants of Cav1 impact caveolae assembly and outline open questions in this still-emerging area.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Czechia 1 2%
Unknown 55 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 32%
Student > Bachelor 8 14%
Researcher 8 14%
Student > Doctoral Student 4 7%
Student > Master 4 7%
Other 6 11%
Unknown 8 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 16 29%
Agricultural and Biological Sciences 12 21%
Medicine and Dentistry 4 7%
Immunology and Microbiology 3 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 6 11%
Unknown 14 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2016.
All research outputs
#17,810,002
of 22,879,161 outputs
Outputs from Frontiers in Cell and Developmental Biology
#4,301
of 9,056 outputs
Outputs of similar age
#252,800
of 352,119 outputs
Outputs of similar age from Frontiers in Cell and Developmental Biology
#21
of 34 outputs
Altmetric has tracked 22,879,161 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,056 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,119 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.