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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Under-Appreciated Promiscuity of the Epidermal Growth Factor Receptor Family
|
|---|---|
| Published in |
Frontiers in Cell and Developmental Biology, August 2016
|
| DOI | 10.3389/fcell.2016.00088 |
| Pubmed ID | |
| Authors |
Sean P. Kennedy, Jordan F. Hastings, Jeremy Z. R. Han, David R. Croucher |
| Abstract |
Each member of the epidermal growth factor receptor (EGFR) family plays a key role in normal development, homeostasis, and a variety of pathophysiological conditions, most notably in cancer. According to the prevailing dogma, these four receptor tyrosine kinases (RTKs; EGFR, ERBB2, ERBB3, and ERBB4) function exclusively through the formation of homodimers and heterodimers within the EGFR family. These combinatorial receptor interactions are known to generate increased interactome diversity and therefore influence signaling output, subcellular localization and function of the heterodimer. This molecular plasticity is also thought to play a role in the development of resistance toward targeted cancer therapies aimed at these known oncogenes. Interestingly, many studies now challenge this dogma and suggest that the potential for EGFR family receptors to interact with more distantly related RTKs is much greater than currently appreciated. Here we discuss how the promiscuity of these oncogenic receptors may lead to the formation of many unexpected receptor pairings and the significant implications for the efficiency of many targeted cancer therapies. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Poland | 1 | 1% |
| Unknown | 89 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 19% |
| Student > Bachelor | 16 | 18% |
| Student > Master | 14 | 16% |
| Researcher | 10 | 11% |
| Student > Doctoral Student | 4 | 4% |
| Other | 14 | 16% |
| Unknown | 15 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 27 | 30% |
| Medicine and Dentistry | 13 | 14% |
| Agricultural and Biological Sciences | 11 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
| Engineering | 5 | 6% |
| Other | 10 | 11% |
| Unknown | 19 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2016.
All research outputs
#18,467,727
of 22,883,326 outputs
Outputs from Frontiers in Cell and Developmental Biology
#4,951
of 9,057 outputs
Outputs of similar age
#263,392
of 343,744 outputs
Outputs of similar age from Frontiers in Cell and Developmental Biology
#22
of 32 outputs
Altmetric has tracked 22,883,326 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,057 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,744 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.