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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer
|
|---|---|
| Published in |
Frontiers in Cell and Developmental Biology, September 2016
|
| DOI | 10.3389/fcell.2016.00103 |
| Pubmed ID | |
| Authors |
Lorraine Burke, Clare T. Butler, Adrian Murphy, Bruce Moran, William M. Gallagher, Jacintha O'Sullivan, Breandán N. Kennedy |
| Abstract |
Colorectal cancer is the third most common cancer worldwide and is associated with significant morbidity and mortality. Current pharmacotherapy options include cytotoxic chemotherapy, anti-VEGF, and anti-EGFR targeting drugs, but these are limited by toxic side effects, limited responses and ultimately resistance. Cysteinyl leukotriene (CysLT) signaling regulates intestinal homeostasis with mounting evidence suggesting that CysLT signaling also plays a role in the pathogenesis of colorectal cancer. Therefore, CysLT signaling represents a novel target for this malignancy. This review evaluates reported links between CysLT signaling and established hallmarks of cancer in addition to its pharmacological potential as a new therapeutic target. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 2 | 29% |
| Unknown | 5 | 71% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 47 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 13 | 28% |
| Student > Bachelor | 9 | 19% |
| Researcher | 5 | 11% |
| Student > Ph. D. Student | 4 | 9% |
| Other | 2 | 4% |
| Other | 4 | 9% |
| Unknown | 10 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 14 | 30% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 9% |
| Medicine and Dentistry | 4 | 9% |
| Agricultural and Biological Sciences | 3 | 6% |
| Immunology and Microbiology | 2 | 4% |
| Other | 7 | 15% |
| Unknown | 13 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2016.
All research outputs
#5,790,560
of 23,321,213 outputs
Outputs from Frontiers in Cell and Developmental Biology
#1,244
of 9,300 outputs
Outputs of similar age
#86,945
of 322,110 outputs
Outputs of similar age from Frontiers in Cell and Developmental Biology
#9
of 41 outputs
Altmetric has tracked 23,321,213 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,300 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,110 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.