While several studies have confirmed a link between mitochondrial DNA (mtDNA) mutations and cancer cell metastasis, much debate remains regarding the nature of the alternations in mtDNA leading to this effect. Meanwhile, the mitochondrial unfolded protein response (UPR(mt)) has gained much attention in recent years, with most studies of this pathway focusing on its role in aging. However, the UPR(mt) has also been studied in the context of cancer. More recent work suggests that rather than a single mutation or alternation, specific combinatorial mtDNA landscapes able to activate the UPR(mt) may be those that are selected by metastatic cells, while mtDNA landscapes unable to activate the UPR(mt) do not. This review aims at offering an overview of the confusing literature on mtDNA mutations and metastasis and the more recent work on the UPR(mt) in this setting.
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2017.
All research outputs
#12,916,103
of 22,965,074 outputs
Outputs from Frontiers in Cell and Developmental Biology
#1,997
of 9,091 outputs
Outputs of similar age
#146,798
of 310,317 outputs
Outputs of similar age from Frontiers in Cell and Developmental Biology
#25
of 44 outputs
Altmetric has tracked 22,965,074 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,091 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,317 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
