Title |
Pancreatic Beta Cell Identity in Humans and the Role of Type 2 Diabetes
|
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Published in |
Frontiers in Cell and Developmental Biology, May 2017
|
DOI | 10.3389/fcell.2017.00055 |
Pubmed ID | |
Authors |
Piero Marchetti, Marco Bugliani, Vincenzo De Tata, Mara Suleiman, Lorella Marselli |
Abstract |
Pancreatic beta cells uniquely synthetize, store, and release insulin. Specific molecular, functional as well as ultrastructural traits characterize their insulin secretion properties and survival phentoype. In this review we focus on human islet/beta cells, and describe the changes that occur in type 2 diabetes and could play roles in the disease as well as represent possible targets for therapeutical interventions. These include transcription factors, molecules involved in glucose metabolism and insulin granule handling. Quantitative and qualitative insulin release patterns and their changes in type 2 diabetes are also associated with ultrastructural features involving the insulin granules, the mitochondria, and the endoplasmic reticulum. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | <1% |
Unknown | 279 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 52 | 19% |
Student > Ph. D. Student | 31 | 11% |
Student > Master | 24 | 9% |
Researcher | 12 | 4% |
Student > Doctoral Student | 11 | 4% |
Other | 26 | 9% |
Unknown | 124 | 44% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 57 | 20% |
Medicine and Dentistry | 25 | 9% |
Agricultural and Biological Sciences | 12 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 4% |
Engineering | 9 | 3% |
Other | 39 | 14% |
Unknown | 128 | 46% |