Title |
Mitochondria and Lysosomes: Discovering Bonds
|
---|---|
Published in |
Frontiers in Cell and Developmental Biology, December 2017
|
DOI | 10.3389/fcell.2017.00106 |
Pubmed ID | |
Authors |
Kiran Todkar, Hema S. Ilamathi, Marc Germain |
Abstract |
In the last decade, the traditional view of lysosomes has been challenged by the recognition that lysosomes are not only degradative organelles, but also metabolic sensors that play a key role in the regulation of metabolism and cell growth. Similarly, mitochondria are now seen as crucial metabolic hubs dictating cell fate decisions, not just ATP-producing machines. Importantly, these functions are generally performed as a coordinate response of distinct organelles that are physically and functionally connected. While the association between mitochondria and the endoplasmic reticulum is well known, a similar interaction between mitochondria and lysosomes is now emerging. This interaction could be required to shuttle amino acids, lipids and ions such as Ca2+ between the two organelles, thereby modulating their metabolic functions. In addition, a tethering complex linking the two organelles has recently been described in yeast, although the mammalian counterpart has yet to be identified. Here, we discuss the implications of these recent findings. |
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Mendeley readers
Geographical breakdown
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Unknown | 181 | 100% |
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Readers by professional status | Count | As % |
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Student > Ph. D. Student | 33 | 18% |
Researcher | 29 | 16% |
Student > Master | 18 | 10% |
Student > Bachelor | 18 | 10% |
Student > Doctoral Student | 8 | 4% |
Other | 28 | 15% |
Unknown | 47 | 26% |
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Medicine and Dentistry | 9 | 5% |
Other | 18 | 10% |
Unknown | 52 | 29% |