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The Ins and Outs of Aurora B Inner Centromere Localization

Overview of attention for article published in Frontiers in Cell and Developmental Biology, December 2017
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2 X users

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Title
The Ins and Outs of Aurora B Inner Centromere Localization
Published in
Frontiers in Cell and Developmental Biology, December 2017
DOI 10.3389/fcell.2017.00112
Pubmed ID
Authors

Sanne Hindriksen, Susanne M. A. Lens, Michael A. Hadders

Abstract

Error-free chromosome segregation is essential for the maintenance of genomic integrity during cell division. Aurora B, the enzymatic subunit of the Chromosomal Passenger Complex (CPC), plays a crucial role in this process. In early mitosis Aurora B localizes predominantly to the inner centromere, a specialized region of chromatin that lies at the crossroads between the inter-kinetochore and inter-sister chromatid axes. Two evolutionarily conserved histone kinases, Haspin and Bub1, control the positioning of the CPC at the inner centromere and this location is thought to be crucial for the CPC to function. However, recent studies sketch a subtler picture, in which not all functions of the CPC require strict confinement to the inner centromere. In this review we discuss the molecular pathways that direct Aurora B to the inner centromere and deliberate if and why this specific localization is important for Aurora B function.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 135 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 135 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 37 27%
Researcher 18 13%
Student > Master 15 11%
Student > Bachelor 10 7%
Professor 5 4%
Other 8 6%
Unknown 42 31%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 53 39%
Agricultural and Biological Sciences 30 22%
Medicine and Dentistry 3 2%
Engineering 2 1%
Mathematics 1 <1%
Other 5 4%
Unknown 41 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2018.
All research outputs
#14,370,803
of 23,012,811 outputs
Outputs from Frontiers in Cell and Developmental Biology
#2,867
of 9,115 outputs
Outputs of similar age
#239,217
of 440,922 outputs
Outputs of similar age from Frontiers in Cell and Developmental Biology
#15
of 30 outputs
Altmetric has tracked 23,012,811 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,115 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 440,922 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.