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X Demographics
Mendeley readers
Attention Score in Context
| Title |
PRDM14 Is a Unique Epigenetic Regulator Stabilizing Transcriptional Networks for Pluripotency
|
|---|---|
| Published in |
Frontiers in Cell and Developmental Biology, February 2018
|
| DOI | 10.3389/fcell.2018.00012 |
| Pubmed ID | |
| Authors |
Yoshiyuki Seki |
| Abstract |
PR-domain containing protein 14 (PRDM14) is a site-specific DNA-binding protein and is required for establishment of pluripotency in embryonic stem cells (ESCs) and primordial germ cells (PGCs) in mice. DNA methylation status is regulated by the balance betweende novomethylation and passive/active demethylation, and global DNA hypomethylation is closely associated with cellular pluripotency and totipotency. PRDM14 ensures hypomethylation in mouse ESCs and PGCs through two distinct layers, transcriptional repression of the DNA methyltransferasesDnmt3a/b/land active demethylation by recruitment of TET proteins. However, the function of PRDM14 remains unclear in other species including humans. Hence, here we focus on the unique characteristics of mouse PRDM14 in the epigenetic regulation of pluripotent cells and primordial germ cells. In addition, we discuss the expression regulation and function of PRDM14 in other species compared with those in mice. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 25% |
| Unknown | 6 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 88% |
| Scientists | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 65 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 18% |
| Researcher | 7 | 11% |
| Student > Bachelor | 6 | 9% |
| Professor > Associate Professor | 5 | 8% |
| Student > Master | 5 | 8% |
| Other | 10 | 15% |
| Unknown | 20 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 31% |
| Agricultural and Biological Sciences | 16 | 25% |
| Chemical Engineering | 2 | 3% |
| Computer Science | 2 | 3% |
| Medicine and Dentistry | 2 | 3% |
| Other | 3 | 5% |
| Unknown | 20 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2018.
All research outputs
#7,645,190
of 26,171,302 outputs
Outputs from Frontiers in Cell and Developmental Biology
#1,872
of 10,616 outputs
Outputs of similar age
#146,397
of 460,644 outputs
Outputs of similar age from Frontiers in Cell and Developmental Biology
#10
of 35 outputs
Altmetric has tracked 26,171,302 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 10,616 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 460,644 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.