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Sleeping Beauty and the Microenvironment Enchantment: Microenvironmental Regulation of the Proliferation-Quiescence Decision in Normal Tissues and in Cancer Development

Overview of attention for article published in Frontiers in Cell and Developmental Biology, June 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

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1 blog
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2 X users

Citations

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47 Dimensions

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79 Mendeley
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Title
Sleeping Beauty and the Microenvironment Enchantment: Microenvironmental Regulation of the Proliferation-Quiescence Decision in Normal Tissues and in Cancer Development
Published in
Frontiers in Cell and Developmental Biology, June 2018
DOI 10.3389/fcell.2018.00059
Pubmed ID
Authors

Ana Paula Zen Petisco Fiore, Pedro de Freitas Ribeiro, Alexandre Bruni-Cardoso

Abstract

Cells from prokaryota to the more complex metazoans cease proliferating at some point in their lives and enter a reversible, proliferative-dormant state termed quiescence. The appearance of quiescence in the course of evolution was essential to the acquisition of multicellular specialization and compartmentalization and is also a central aspect of tissue function and homeostasis. But what makes a cell cease proliferating even in the presence of nutrients, growth factors, and mitogens? And what makes some cells "wake up" when they should not, as is the case in cancer? Here, we summarize and discuss evidence showing how microenvironmental cues such as those originating from metabolism, extracellular matrix (ECM) composition and arrangement, neighboring cells and tissue architecture control the cellular proliferation-quiescence decision, and how this complex regulation is corrupted in cancer.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 79 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 18%
Researcher 12 15%
Student > Master 8 10%
Student > Bachelor 7 9%
Student > Doctoral Student 6 8%
Other 10 13%
Unknown 22 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 23 29%
Agricultural and Biological Sciences 10 13%
Medicine and Dentistry 6 8%
Neuroscience 3 4%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Other 9 11%
Unknown 25 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2023.
All research outputs
#4,762,951
of 25,954,278 outputs
Outputs from Frontiers in Cell and Developmental Biology
#1,138
of 10,601 outputs
Outputs of similar age
#83,428
of 344,509 outputs
Outputs of similar age from Frontiers in Cell and Developmental Biology
#6
of 29 outputs
Altmetric has tracked 25,954,278 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,601 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,509 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.