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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Serum Antibodies Against Simian Virus 40 Large T Antigen, the Viral Oncoprotein, in Osteosarcoma Patients
|
|---|---|
| Published in |
Frontiers in Cell and Developmental Biology, June 2018
|
| DOI | 10.3389/fcell.2018.00064 |
| Pubmed ID | |
| Authors |
Elisa Mazzoni, Ilaria Bononi, Maria S. Benassi, Piero Picci, Elena Torreggiani, Marika Rossini, Andrea Simioli, Maria V. Casali, Paola Rizzo, Mauro Tognon, Fernanda Martini |
| Abstract |
Human osteosarcoma (OS) is a rare human cancer, mostly occurring in children and adolescents. Simian virus 40 (SV40 = Macaca mulatta polyomavirus 1) sequences have been detected in different human cancers, including osteosarcoma. SV40 is an oncogenic virus in vivo, whereas it transforms different kinds of mammalian cells, as well as distinct human cell types. SV40 injected in rodents induces tumors of different histotypes, such as bone and brain tumors. Herein, the association between OS and SV40 large T antigen (Tag) was studied by employing indirect ELISAs using synthetic peptides that mimic different epitopes of the SV40 Tag, the viral oncoprotein. Indirect ELISAs were used to detect serum IgG antibodies against this oncogenic virus in samples from OS patients. Controls were sera from healthy subjects (HS) and oncological patients affect by breast cancer (BC), which is not associated with SV40. It turned out that sera of OS patients had a higher prevalence of SV40 Tag antibodies, 35%, compared to HS, 20% and BC, 19%, respectively. The different prevalence of SV40 Tag antibodies revealed in OS vs. HS and vs. BC is statistically significant with P < 0.05 and P < 0.01, respectively. Our immunological data indicate a significantly higher prevalence of antibodies against SV40 Tag epitopes in serum samples from OS patients compared to HS and BC, the controls. These results suggest an association between OS and SV40 Tag, indicating that this oncogenic virus may be a cofactor in OS development. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 43% |
| United Kingdom | 1 | 14% |
| Germany | 1 | 14% |
| Portugal | 1 | 14% |
| Switzerland | 1 | 14% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 71% |
| Scientists | 1 | 14% |
| Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 2 | 29% |
| Unspecified | 1 | 14% |
| Unknown | 4 | 57% |
| Readers by discipline | Count | As % |
|---|---|---|
| Unspecified | 1 | 14% |
| Biochemistry, Genetics and Molecular Biology | 1 | 14% |
| Medicine and Dentistry | 1 | 14% |
| Unknown | 4 | 57% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2021.
All research outputs
#6,599,307
of 23,342,092 outputs
Outputs from Frontiers in Cell and Developmental Biology
#1,523
of 9,316 outputs
Outputs of similar age
#114,587
of 329,407 outputs
Outputs of similar age from Frontiers in Cell and Developmental Biology
#9
of 32 outputs
Altmetric has tracked 23,342,092 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 9,316 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,407 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.