Title |
Endothelial Cell Metabolism in Atherosclerosis
|
---|---|
Published in |
Frontiers in Cell and Developmental Biology, August 2018
|
DOI | 10.3389/fcell.2018.00082 |
Pubmed ID | |
Authors |
Kosta Theodorou, Reinier A. Boon |
Abstract |
Atherosclerosis and its sequelae, such as myocardial infarction and stroke, are the leading cause of death worldwide. Vascular endothelial cells (EC) play a critical role in vascular homeostasis and disease. Atherosclerosis as well as its independent risk factors including diabetes, obesity, and aging, are hallmarked by endothelial activation and dysfunction. Metabolic pathways have emerged as key regulators of many EC functions, including angiogenesis, inflammation, and barrier function, processes which are deregulated during atherogenesis. In this review, we highlight the role of glucose, fatty acid, and amino acid metabolism in EC functions during physiological and pathological states, specifically atherosclerosis, diabetes, obesity and aging. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 20% |
United Kingdom | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 3 | 60% |
Members of the public | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 134 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 24 | 18% |
Student > Bachelor | 14 | 10% |
Researcher | 13 | 10% |
Student > Master | 12 | 9% |
Student > Doctoral Student | 12 | 9% |
Other | 22 | 16% |
Unknown | 37 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 34 | 25% |
Medicine and Dentistry | 25 | 19% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
Nursing and Health Professions | 5 | 4% |
Agricultural and Biological Sciences | 4 | 3% |
Other | 19 | 14% |
Unknown | 41 | 31% |