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Genus Cistus: a model for exploring labdane-type diterpenes' biosynthesis and a natural source of high value products with biological, aromatic, and pharmacological properties

Overview of attention for article published in Frontiers in Chemistry, June 2014
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Title
Genus Cistus: a model for exploring labdane-type diterpenes' biosynthesis and a natural source of high value products with biological, aromatic, and pharmacological properties
Published in
Frontiers in Chemistry, June 2014
DOI 10.3389/fchem.2014.00035
Pubmed ID
Authors

Dimitra Papaefthimiou, Antigoni Papanikolaou, Vasiliki Falara, Stella Givanoudi, Stefanos Kostas, Angelos K. Kanellis

Abstract

The family Cistaceae (Angiosperm, Malvales) consists of 8 genera and 180 species, with 5 genera native to the Mediterranean area (Cistus, Fumara, Halimium, Helianthemum, and Tuberaria). Traditionally, a number of Cistus species have been used in Mediterranean folk medicine as herbal tea infusions for healing digestive problems and colds, as extracts for the treatment of diseases, and as fragrances. The resin, ladano, secreted by the glandular trichomes of certain Cistus species contains a number of phytochemicals with antioxidant, antibacterial, antifungal, and anticancer properties. Furthermore, total leaf aqueous extracts possess anti-influenza virus activity. All these properties have been attributed to phytochemicals such as terpenoids, including diterpenes, labdane-type diterpenes and clerodanes, phenylpropanoids, including flavonoids and ellagitannins, several groups of alkaloids and other types of secondary metabolites. In the past 20 years, research on Cistus involved chemical, biological and phylogenetic analyses but recent investigations have involved genomic and molecular approaches. Our lab is exploring the biosynthetic machinery that generates terpenoids and phenylpropanoids, with a goal to harness their numerous properties that have applications in the pharmaceutical, chemical and aromatic industries. This review focuses on the systematics, botanical characteristics, geographic distribution, chemical analyses, biological function and biosynthesis of major compounds, as well as genomic analyses and biotechnological approaches of the main Cistus species found in the Mediterranean basin, namely C. albidus, C. creticus, C. crispus, C. parviflorus, C. monspeliensis, C. populifolius, C. salviifolius, C. ladanifer, C. laurifolius, and C. clusii.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Serbia 1 <1%
Unknown 145 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 14%
Researcher 21 14%
Student > Master 20 14%
Student > Bachelor 8 5%
Student > Postgraduate 6 4%
Other 20 14%
Unknown 50 34%
Readers by discipline Count As %
Agricultural and Biological Sciences 33 23%
Biochemistry, Genetics and Molecular Biology 16 11%
Pharmacology, Toxicology and Pharmaceutical Science 15 10%
Chemistry 8 5%
Nursing and Health Professions 3 2%
Other 12 8%
Unknown 59 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2014.
All research outputs
#21,505,751
of 26,397,269 outputs
Outputs from Frontiers in Chemistry
#2,613
of 6,894 outputs
Outputs of similar age
#180,760
of 244,674 outputs
Outputs of similar age from Frontiers in Chemistry
#19
of 33 outputs
Altmetric has tracked 26,397,269 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,894 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,674 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.