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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Small-Molecule Binding Aptamers: Selection Strategies, Characterization, and Applications
|
|---|---|
| Published in |
Frontiers in Chemistry, May 2016
|
| DOI | 10.3389/fchem.2016.00014 |
| Pubmed ID | |
| Authors |
Annamaria Ruscito, Maria C. DeRosa |
| Abstract |
Aptamers are single-stranded, synthetic oligonucleotides that fold into 3-dimensional shapes capable of binding non-covalently with high affinity and specificity to a target molecule. They are generated via an in vitro process known as the Systematic Evolution of Ligands by EXponential enrichment, from which candidates are screened and characterized, and then used in various applications. These applications range from therapeutic uses to biosensors for target detection. Aptamers for small molecule targets such as toxins, antibiotics, molecular markers, drugs, and heavy metals will be the focus of this review. Their accurate detection is needed for the protection and wellbeing of humans and animals. However, the small molecular weights of these targets, including the drastic size difference between the target and the oligonucleotides, make it challenging to select, characterize, and apply aptamers for their detection. Thus, recent (since 2012) notable advances in small molecule aptamers, which have overcome some of these challenges, are presented here, while defining challenges that still exist are discussed. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 33% |
| Canada | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 4 | 67% |
| Members of the public | 2 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 582 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | <1% |
| United Kingdom | 1 | <1% |
| Belgium | 1 | <1% |
| China | 1 | <1% |
| Qatar | 1 | <1% |
| Unknown | 577 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 131 | 23% |
| Researcher | 80 | 14% |
| Student > Bachelor | 72 | 12% |
| Student > Master | 71 | 12% |
| Student > Doctoral Student | 31 | 5% |
| Other | 61 | 10% |
| Unknown | 136 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 134 | 23% |
| Chemistry | 129 | 22% |
| Agricultural and Biological Sciences | 58 | 10% |
| Engineering | 34 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 13 | 2% |
| Other | 50 | 9% |
| Unknown | 164 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2020.
All research outputs
#4,329,686
of 23,567,572 outputs
Outputs from Frontiers in Chemistry
#293
of 6,195 outputs
Outputs of similar age
#67,274
of 306,563 outputs
Outputs of similar age from Frontiers in Chemistry
#3
of 16 outputs
Altmetric has tracked 23,567,572 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,195 research outputs from this source. They receive a mean Attention Score of 2.1. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,563 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.