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Base-Modified Nucleosides: Etheno Derivatives

Overview of attention for article published in Frontiers in Chemistry, April 2016
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Title
Base-Modified Nucleosides: Etheno Derivatives
Published in
Frontiers in Chemistry, April 2016
DOI 10.3389/fchem.2016.00019
Pubmed ID
Authors

Zofia Jahnz-Wechmann, Grzegorz R. Framski, Piotr A. Januszczyk, Jerzy Boryski

Abstract

This review presents synthesis and chemistry of nucleoside analogs, possessing an additional fused, heterocyclic ring of the "etheno" type, such as 1,N(6)-ethenoadenosine, 1,N(4)-ethenocytidine, 1,N(2)-ethenoguanosine, and other related derivatives. Formation of ethenonucleosides, in the presence of α-halocarbonyl reagents and their mechanism, stability, and degradation, reactions of substitution and transglycosylation, as well as their application in the nucleoside synthesis, have been described. Some of the discussed compounds may be applied as chemotherapeutic agents in antiviral and anticancer treatment, acting as pro-nucleosides of already known, biologically active nucleoside analogs.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 20%
Professor > Associate Professor 3 12%
Researcher 3 12%
Professor 2 8%
Student > Master 2 8%
Other 3 12%
Unknown 7 28%
Readers by discipline Count As %
Chemistry 11 44%
Biochemistry, Genetics and Molecular Biology 5 20%
Neuroscience 1 4%
Unknown 8 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2016.
All research outputs
#18,453,763
of 22,865,319 outputs
Outputs from Frontiers in Chemistry
#2,218
of 5,958 outputs
Outputs of similar age
#218,953
of 299,113 outputs
Outputs of similar age from Frontiers in Chemistry
#9
of 14 outputs
Altmetric has tracked 22,865,319 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,958 research outputs from this source. They receive a mean Attention Score of 2.0. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 299,113 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.