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Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration

Overview of attention for article published in Frontiers in Chemistry, October 2017
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Title
Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration
Published in
Frontiers in Chemistry, October 2017
DOI 10.3389/fchem.2017.00089
Pubmed ID
Authors

Yun Qian, Qixin Han, Wei Chen, Jialin Song, Xiaotian Zhao, Yuanming Ouyang, Weien Yuan, Cunyi Fan

Abstract

Stem cell treatment and platelet-rich plasma (PRP) therapy are two significant issues in regenerative medicine. Stem cells such as bone marrow mesenchymal stem cells, adipose-derived stem cells and periodontal ligament stem cells can be successfully applied in the field of tissue regeneration. PRP, a natural product isolated from whole blood, can secrete multiple growth factors (GFs) for regulating physiological activities. These GFs can stimulate proliferation and differentiation of different stem cells in injury models. Therefore, combination of both agents receives wide expectations in regenerative medicine, especially in bone, cartilage and tendon repair. In this review, we thoroughly discussed the interaction and underlying mechanisms of PRP derived GFs with stem cells, and assessed their functions in cell differentiation for musculoskeletal regeneration.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 170 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 170 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 13%
Student > Bachelor 20 12%
Student > Ph. D. Student 16 9%
Student > Master 13 8%
Other 10 6%
Other 26 15%
Unknown 63 37%
Readers by discipline Count As %
Medicine and Dentistry 45 26%
Biochemistry, Genetics and Molecular Biology 11 6%
Agricultural and Biological Sciences 11 6%
Veterinary Science and Veterinary Medicine 6 4%
Engineering 4 2%
Other 21 12%
Unknown 72 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2017.
All research outputs
#20,451,228
of 23,007,053 outputs
Outputs from Frontiers in Chemistry
#2,935
of 6,008 outputs
Outputs of similar age
#286,637
of 328,927 outputs
Outputs of similar age from Frontiers in Chemistry
#27
of 49 outputs
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We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.