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Application of Light Scattering Techniques to Nanoparticle Characterization and Development

Overview of attention for article published in Frontiers in Chemistry, June 2018
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  • Good Attention Score compared to outputs of the same age and source (77th percentile)

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Title
Application of Light Scattering Techniques to Nanoparticle Characterization and Development
Published in
Frontiers in Chemistry, June 2018
DOI 10.3389/fchem.2018.00237
Pubmed ID
Authors

Patrícia M. Carvalho, Mário R. Felício, Nuno C. Santos, Sónia Gonçalves, Marco M. Domingues

Abstract

Over the years, the scientific importance of nanoparticles for biomedical applications has increased. The high stability and biocompatibility, together with the low toxicity of the nanoparticles developed lead to their use as targeted drug delivery systems, bioimaging systems, and biosensors. The wide range of nanoparticles size, from 10 nm to 1 μm, as well as their optical properties, allow them to be studied using microscopy and spectroscopy techniques. In order to be effectively used, the physicochemical properties of nanoparticle formulations need to be taken into account, namely, particle size, surface charge distribution, surface derivatization and/or loading capacity, and related interactions. These properties need to be optimized considering the final nanoparticle intended biodistribution and target. In this review, we cover light scattering based techniques, namely dynamic light scattering and zeta-potential, used for the physicochemical characterization of nanoparticles. Dynamic light scattering is used to measure nanoparticles size, but also to evaluate their stability over time in suspension, at different pH and temperature conditions. Zeta-potential is used to characterize nanoparticles surface charge, obtaining information about their stability and surface interaction with other molecules. In this review, we focus on nanoparticle characterization and application in infection, cancer and cardiovascular diseases.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 674 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 674 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 91 14%
Student > Bachelor 83 12%
Student > Master 77 11%
Researcher 42 6%
Student > Doctoral Student 32 5%
Other 68 10%
Unknown 281 42%
Readers by discipline Count As %
Chemistry 87 13%
Biochemistry, Genetics and Molecular Biology 64 9%
Engineering 47 7%
Pharmacology, Toxicology and Pharmaceutical Science 46 7%
Materials Science 32 5%
Other 97 14%
Unknown 301 45%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2020.
All research outputs
#14,134,028
of 23,092,602 outputs
Outputs from Frontiers in Chemistry
#929
of 6,038 outputs
Outputs of similar age
#180,134
of 328,981 outputs
Outputs of similar age from Frontiers in Chemistry
#36
of 166 outputs
Altmetric has tracked 23,092,602 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,038 research outputs from this source. They receive a mean Attention Score of 2.1. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,981 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 166 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.