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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Extracts of Physalis peruviana Protect Astrocytic Cells Under Oxidative Stress With Rotenone
|
|---|---|
| Published in |
Frontiers in Chemistry, July 2018
|
| DOI | 10.3389/fchem.2018.00276 |
| Pubmed ID | |
| Authors |
Natalia Areiza-Mazo, Jorge Robles, Jairo A. Zamudio-Rodriguez, Lisandro Giraldez, Valentina Echeverria, Biviana Barrera-Bailon, Gjumrakch Aliev, Amirhossein Sahebkar, Ghulam Md Ashraf, George E. Barreto |
| Abstract |
The use of medicinal plants to counteract the oxidative damage in neurodegenerative diseases has steadily increased over the last few years. However, the rationale for using these natural compounds and their therapeutic benefit are not well explored. In this study, we evaluated the effect of different Physalis peruviana extracts on astrocytic cells (T98G) subjected to oxidative damage induced by rotenone. Extracts of fresh and dehydrated fruits of the plant with different polarities were prepared and tested in vitro. Our results demonstrated that the ethanolic extract of fresh fruits (EF) and acetone-dehydrated fruit extract (AD) increased cell viability, reduced the formation of reactive oxygen species (ROS) and preserved mitochondrial membrane potential. In contrast, we observed a significant reduction in mitochondrial mass when rotenone-treated cells were co-treated with EF and AD. These effects were accompanied by a reduction in the percentage of cells with fragmented/condensed nuclei and increased expression of endogenous antioxidant defense survival proteins such as ERK1/2. In conclusion, our findings suggest that ethanolic and acetone extracts from P. peruviana are potential medicinal plant extracts to overcome oxidative damage induced by neurotoxic compounds. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 66 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 14% |
| Student > Bachelor | 9 | 14% |
| Student > Master | 8 | 12% |
| Student > Doctoral Student | 4 | 6% |
| Student > Postgraduate | 4 | 6% |
| Other | 13 | 20% |
| Unknown | 19 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 11 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 14% |
| Biochemistry, Genetics and Molecular Biology | 7 | 11% |
| Neuroscience | 5 | 8% |
| Engineering | 3 | 5% |
| Other | 10 | 15% |
| Unknown | 21 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2018.
All research outputs
#20,527,576
of 23,096,849 outputs
Outputs from Frontiers in Chemistry
#2,950
of 6,040 outputs
Outputs of similar age
#287,428
of 328,924 outputs
Outputs of similar age from Frontiers in Chemistry
#116
of 180 outputs
Altmetric has tracked 23,096,849 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,040 research outputs from this source. They receive a mean Attention Score of 2.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,924 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 180 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.