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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Selective Targeting of Proteins by Hybrid Polyoxometalates: Interaction Between a Bis-Biotinylated Hybrid Conjugate and Avidin
|
|---|---|
| Published in |
Frontiers in Chemistry, July 2018
|
| DOI | 10.3389/fchem.2018.00278 |
| Pubmed ID | |
| Authors |
Valeria A. Zamolo, Gloria Modugno, Elisa Lubian, Alessandro Cazzolaro, Fabrizio Mancin, Livia Giotta, Disma Mastrogiacomo, Ludovico Valli, Alessandra Saccani, Silke Krol, Marcella Bonchio, Mauro Carraro |
| Abstract |
The Keggin-type polyoxometalate [γ-SiW10O36]8- was covalently modified to obtain a bis-biotinylated conjugate able to bind avidin. Spectroscopic studies such as UV-vis, fluorimetry, circular dichroism, coupled to surface plasmon resonance technique were used to highlight the unique interplay of supramolecular interactions between the homotetrameric protein and the bis-functionalized polyanion. In particular, the dual recognition mechanism of the avidin encompasses (i) a complementary electrostatic association between the anionic surface of the polyoxotungstate and each positively charged avidin subunit and (ii) specific host-guest interactions between each biotinylated arm and a corresponding pocket on the tetramer subunits. The assembly exhibits peroxidase-like reactivity and it was used in aqueous solution for L-methionine methyl ester oxidation by H2O2. The recognition phenomenon was then exploited for the preparation of layer-by-layer films, whose structural evolution was monitored in situ by ATR-FTIR spectroscopy. Finally, cell tracking studies were performed by exploiting the specific interactions with a labeled streptavidin. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Thailand | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 24% |
| Researcher | 4 | 14% |
| Student > Ph. D. Student | 3 | 10% |
| Other | 1 | 3% |
| Student > Postgraduate | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 13 | 45% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 9 | 31% |
| Materials Science | 2 | 7% |
| Agricultural and Biological Sciences | 1 | 3% |
| Chemical Engineering | 1 | 3% |
| Engineering | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 15 | 52% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2018.
All research outputs
#15,539,088
of 23,094,276 outputs
Outputs from Frontiers in Chemistry
#1,601
of 6,038 outputs
Outputs of similar age
#208,614
of 326,767 outputs
Outputs of similar age from Frontiers in Chemistry
#61
of 178 outputs
Altmetric has tracked 23,094,276 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,038 research outputs from this source. They receive a mean Attention Score of 2.0. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 326,767 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 178 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.