Title |
Talaropeptides A-D: Structure and Biosynthesis of Extensively N-methylated Linear Peptides From an Australian Marine Tunicate-Derived Talaromyces sp.
|
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Published in |
Frontiers in Chemistry, September 2018
|
DOI | 10.3389/fchem.2018.00394 |
Pubmed ID | |
Authors |
Pradeep Dewapriya, Zeinab G. Khalil, Pritesh Prasad, Angela A. Salim, Pablo Cruz-Morales, Esteban Marcellin, Robert J. Capon |
Abstract |
An Australian marine tunicate-derived fungus, Talaromyces sp. CMB-TU011 was subjected to a program of analytical microbioreactor (MATRIX) cultivations, supported by UHPLC-QTOF profiling, to reveal conditions for producing a new class of extensively N-methylated 11-12 residue linear peptides, talaropeptides A-D (2-5). The structures for 2-5, inclusive of absolute configurations, were determined by a combination of detailed spectroscopic and chemical (e.g., C3 and C18 Marfey's) analyses. We report on the biological properties of 2-5, including plasma stability, as well as antibacterial, antifungal and cell cytotoxicity. The talaropeptide mega non-ribosomal peptide synthetase (NRPS) is described, as second only in size to that for the fungus-derived immunosuppressant cyclosporine (an 11-residue extensively N-methylated cyclic peptide). |
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Geographical breakdown
Country | Count | As % |
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Australia | 1 | 25% |
United States | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 50% |
Scientists | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 24% |
Other | 2 | 10% |
Lecturer | 2 | 10% |
Unspecified | 1 | 5% |
Student > Master | 1 | 5% |
Other | 1 | 5% |
Unknown | 9 | 43% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 4 | 19% |
Chemistry | 2 | 10% |
Unspecified | 1 | 5% |
Immunology and Microbiology | 1 | 5% |
Agricultural and Biological Sciences | 1 | 5% |
Other | 2 | 10% |
Unknown | 10 | 48% |