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X Demographics
Mendeley readers
Attention Score in Context
| Title |
AI-2 of Aggregatibacter actinomycetemcomitans inhibits Candida albicans biofilm formation
|
|---|---|
| Published in |
Frontiers in Cellular and Infection Microbiology, July 2014
|
| DOI | 10.3389/fcimb.2014.00094 |
| Pubmed ID | |
| Authors |
Endang W. Bachtiar, Boy M. Bachtiar, Lucja M. Jarosz, Lisa R. Amir, Hari Sunarto, Hadas Ganin, Michael M. Meijler, Bastiaan P. Krom |
| Abstract |
Aggregatibacter actinomycetemcomitans, a Gram-negative bacterium, and Candida albicans, a polymorphic fungus, are both commensals of the oral cavity but both are opportunistic pathogens that can cause oral diseases. A. actinomycetemcomitans produces a quorum-sensing molecule called autoinducer-2 (AI-2), synthesized by LuxS, that plays an important role in expression of virulence factors, in intra- but also in interspecies communication. The aim of this study was to investigate the role of AI-2 based signaling in the interactions between C. albicans and A. actinomycetemcomitans. A. actinomycetemcomitans adhered to C. albicans and inhibited biofilm formation by means of a molecule that was secreted during growth. C. albicans biofilm formation increased significantly when co-cultured with A. actinomycetemcomitans luxS, lacking AI-2 production. Addition of wild-type-derived spent medium or synthetic AI-2 to spent medium of the luxS strain, restored inhibition of C. albicans biofilm formation to wild-type levels. Addition of synthetic AI-2 significantly inhibited hypha formation of C. albicans possibly explaining the inhibition of biofilm formation. AI-2 of A. actinomycetemcomitans is synthesized by LuxS, accumulates during growth and inhibits C. albicans hypha- and biofilm formation. Identifying the molecular mechanisms underlying the interaction between bacteria and fungi may provide important insight into the balance within complex oral microbial communities. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| India | 1 | <1% |
| Unknown | 106 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 16% |
| Student > Master | 15 | 14% |
| Researcher | 14 | 13% |
| Student > Bachelor | 14 | 13% |
| Student > Doctoral Student | 6 | 6% |
| Other | 20 | 19% |
| Unknown | 22 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 22% |
| Biochemistry, Genetics and Molecular Biology | 16 | 15% |
| Medicine and Dentistry | 14 | 13% |
| Immunology and Microbiology | 12 | 11% |
| Chemistry | 4 | 4% |
| Other | 13 | 12% |
| Unknown | 25 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2018.
All research outputs
#15,302,068
of 22,757,541 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#3,500
of 6,348 outputs
Outputs of similar age
#132,193
of 228,565 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#14
of 28 outputs
Altmetric has tracked 22,757,541 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,348 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,565 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.