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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Multiple Phenotypic Changes Define Neutrophil Priming
|
|---|---|
| Published in |
Frontiers in Cellular and Infection Microbiology, May 2017
|
| DOI | 10.3389/fcimb.2017.00217 |
| Pubmed ID | |
| Authors |
Irina Miralda, Silvia M. Uriarte, Kenneth R. McLeish |
| Abstract |
Exposure to pro-inflammatory cytokines, chemokines, mitochondrial contents, and bacterial and viral products induces neutrophils to transition from a basal state into a primed one, which is currently defined as an enhanced response to activating stimuli. Although, typically associated with enhanced generation of reactive oxygen species (ROS) by the NADPH oxidase, primed neutrophils show enhanced responsiveness of exocytosis, NET formation, and chemotaxis. Phenotypic changes associated with priming also include activation of a subset of functions, including adhesion, transcription, metabolism, and rate of apoptosis. This review summarizes the breadth of phenotypic changes associated with priming and reviews current knowledge of the molecular mechanisms behind those changes. We conclude that the current definition of priming is too restrictive. Priming represents a combination of enhanced responsiveness and activated functions that regulate both adaptive and innate immune responses. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 218 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | <1% |
| Unknown | 217 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 44 | 20% |
| Student > Master | 27 | 12% |
| Researcher | 25 | 11% |
| Student > Bachelor | 25 | 11% |
| Student > Doctoral Student | 12 | 6% |
| Other | 26 | 12% |
| Unknown | 59 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 48 | 22% |
| Biochemistry, Genetics and Molecular Biology | 35 | 16% |
| Medicine and Dentistry | 29 | 13% |
| Agricultural and Biological Sciences | 24 | 11% |
| Engineering | 4 | 2% |
| Other | 15 | 7% |
| Unknown | 63 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2017.
All research outputs
#17,897,310
of 22,977,819 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#4,140
of 6,474 outputs
Outputs of similar age
#224,619
of 314,113 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#134
of 186 outputs
Altmetric has tracked 22,977,819 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,474 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,113 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 186 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.