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Methods to Illuminate the Role of Salmonella Effector Proteins during Infection: A Review

Overview of attention for article published in Frontiers in Cellular and Infection Microbiology, August 2017
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  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

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Title
Methods to Illuminate the Role of Salmonella Effector Proteins during Infection: A Review
Published in
Frontiers in Cellular and Infection Microbiology, August 2017
DOI 10.3389/fcimb.2017.00363
Pubmed ID
Authors

Alexandra M. Young, Amy E. Palmer

Abstract

Intracellular bacterial pathogens like Salmonella enterica use secretion systems, such as the Type III Secretion System, to deliver virulence factors into host cells in order to invade and colonize these cells. Salmonella virulence factors include a suite of effector proteins that remodel the host cell to facilitate bacterial internalization, replication, and evasion of host immune surveillance. A number of diverse and innovative approaches have been used to identify and characterize the role of effector proteins during infection. Recent techniques for studying infection using single cell and animal models have illuminated the contribution of individual effector proteins in infection. This review will highlight the techniques applied to study Salmonella effector proteins during infection. It will describe how different approaches have revealed mechanistic details for effectors in manipulating host cellular processes including: the dynamics of effector translocation into host cells, cytoskeleton reorganization, membrane trafficking, gene regulation, and autophagy.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 95 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 25%
Student > Master 14 15%
Student > Bachelor 7 7%
Researcher 7 7%
Student > Doctoral Student 6 6%
Other 6 6%
Unknown 31 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 22 23%
Agricultural and Biological Sciences 16 17%
Immunology and Microbiology 13 14%
Veterinary Science and Veterinary Medicine 4 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 1%
Other 5 5%
Unknown 34 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2017.
All research outputs
#13,491,001
of 22,997,544 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#2,210
of 6,493 outputs
Outputs of similar age
#159,259
of 318,015 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#51
of 129 outputs
Altmetric has tracked 22,997,544 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,493 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 318,015 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 129 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.