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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Identification and Characterization of an Antibacterial Type VI Secretion System in the Carbapenem-Resistant Strain Klebsiella pneumoniae HS11286
|
|---|---|
| Published in |
Frontiers in Cellular and Infection Microbiology, October 2017
|
| DOI | 10.3389/fcimb.2017.00442 |
| Pubmed ID | |
| Authors |
Lu Liu, Meiping Ye, Xiaobin Li, Jun Li, Zixin Deng, Yu-Feng Yao, Hong-Yu Ou |
| Abstract |
The type VI secretion system (T6SS) is a class of sophisticated cell contact-dependent apparatus with anti-eukaryotic or anti-bacterial function. Klebsiella pneumoniae is one of the most common bacterial pathogens with resistance to the carbapenem antibiotics. However, little is known about the antibacterial T6SS in K. pneumoniae. Using core-component protein searches, we identified a putative T6SS gene cluster on the chromosome of the carbapenemase-producing K. pneumoniae (CRKP) strain HS11286. Intraspecies and interspecies competition assays revealed an antibacterial function of the HS11286 T6SS. The phospholipase Tle1(KP) was found to be an effector protein that is transferred by T6SS. The overexpression of this effector gene in the periplasm caused severe growth inhibition of Escherichia coli. A sub-inhibitory concentration of β-lactam antibiotics stimulated the expression and secretion of the HS11286 T6SS and enhanced T6SS-dependent killing. It suggested that the antibiotics might be an impact factor for the T6SS secretion and antibacterial activity. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 11% |
| Unknown | 8 | 89% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 6 | 67% |
| Members of the public | 3 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 102 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 16% |
| Student > Ph. D. Student | 15 | 15% |
| Student > Bachelor | 15 | 15% |
| Researcher | 6 | 6% |
| Student > Postgraduate | 4 | 4% |
| Other | 15 | 15% |
| Unknown | 31 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 24 | 24% |
| Immunology and Microbiology | 17 | 17% |
| Agricultural and Biological Sciences | 14 | 14% |
| Medicine and Dentistry | 4 | 4% |
| Chemistry | 3 | 3% |
| Other | 8 | 8% |
| Unknown | 32 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2017.
All research outputs
#6,760,998
of 24,093,053 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#1,350
of 7,271 outputs
Outputs of similar age
#105,434
of 328,398 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#24
of 96 outputs
Altmetric has tracked 24,093,053 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 7,271 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,398 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 96 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.