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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Autoregulation of ToxR and Its Regulatory Actions on Major Virulence Gene Loci in Vibrio parahaemolyticus
|
|---|---|
| Published in |
Frontiers in Cellular and Infection Microbiology, September 2018
|
| DOI | 10.3389/fcimb.2018.00291 |
| Pubmed ID | |
| Authors |
Yiquan Zhang, Lingfei Hu, George Osei-Adjei, Ying Zhang, Wenhui Yang, Zhe Yin, Renyun Lu, Xiumei Sheng, Ruifu Yang, Xinxiang Huang, Dongsheng Zhou |
| Abstract |
Vibrio parahaemolyticus, the leading causative agent of seafood-associated gastroenteritis, harbors two major virulence gene loci T3SS1 and Vp-PAI (T3SS2 and tdh2). ToxR is a virulence regulator of vibrios. Cell density-dependent transcriptional pattern of toxR and its regulatory actions on T3SS1 and Vp-PAI have been previously reported, but the detailed regulatory mechanisms are still obscure. In the present work, we showed that the highest transcription level of toxR occurs at an OD600 = 0.2-0.4, which may be due to the subtle repression of ToxR and the quorum-sensing (QS) master regulator AphA. We also showed that ToxR is involved in regulating the mouse lethality, enterotoxicity, cytotoxicity, and hemolytic activity of V. parahaemolyticus. ToxR binds to the multiple promoter-proximal DNA regions within the T3SS1 locus to repress their transcription. In addition, ToxR occupies the multiple promoter-proximal DNA regions of Vp-PAI locus to activate their transcription. Thus, ToxR regulates the multiple virulence phenotypes via directly acting on the T3SS1 and Vp-PAI genes. Data presented here provide a deeper understanding of the regulatory patterns of ToxR in V. parahaemolyticus. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 39 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 21% |
| Student > Bachelor | 7 | 18% |
| Student > Ph. D. Student | 5 | 13% |
| Student > Master | 5 | 13% |
| Student > Doctoral Student | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 13 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 26% |
| Immunology and Microbiology | 4 | 10% |
| Agricultural and Biological Sciences | 4 | 10% |
| Nursing and Health Professions | 2 | 5% |
| Environmental Science | 2 | 5% |
| Other | 5 | 13% |
| Unknown | 12 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2018.
All research outputs
#17,989,170
of 23,102,082 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#4,210
of 6,567 outputs
Outputs of similar age
#240,932
of 335,873 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#67
of 101 outputs
Altmetric has tracked 23,102,082 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,567 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,873 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 101 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.