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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Staphylococcal Enterotoxins Dose-Dependently Modulate the Generation of Myeloid-Derived Suppressor Cells
|
|---|---|
| Published in |
Frontiers in Cellular and Infection Microbiology, September 2018
|
| DOI | 10.3389/fcimb.2018.00321 |
| Pubmed ID | |
| Authors |
Hartmut Stoll, Michael Ost, Anurag Singh, Roman Mehling, Davide Neri, Iris Schäfer, Ana Velic, Boris Macek, Dorothee Kretschmer, Christopher Weidenmaier, Andreas Hector, Rupert Handgretinger, Friedrich Götz, Andreas Peschel, Dominik Hartl, Nikolaus Rieber |
| Abstract |
Staphylococcus aureus is one of the major human bacterial pathogens causing a broad spectrum of serious infections. Myeloid-derived suppressor cells (MDSC) represent an innate immune cell subset capable of regulating host-pathogen interactions, yet their role in the pathogenesis of S. aureus infections remains incompletely defined. The aim of this study was to determine the influence of different S. aureus strains and associated virulence factors on human MDSC generation. Using an in vitro MDSC generation assay we demonstrate that low concentrations of supernatants of different S. aureus strains led to an induction of functional MDSC, whereas increased concentrations, conversely, reduced MDSC numbers. The concentration-dependent reduction of MDSC correlated with T cell proliferation and cytotoxicity. Several findings supported a role for staphylococcal enterotoxins in modulating MDSC generation. Staphylococcal enterotoxins recapitulated concentration-dependent MDSC induction and inhibition, T cell proliferation and cytotoxicity, while an enterotoxin-deficient S. aureus strain largely failed to alter MDSC. Taken together, we identified staphylococcal enterotoxins as main modulators of MDSC generation. The inhibition of MDSC generation by staphylococcal enterotoxins might represent a novel therapeutic target in S. aureus infections and beyond in non-infectious conditions, such as cancer. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 17% |
| Finland | 1 | 17% |
| Switzerland | 1 | 17% |
| United Kingdom | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 40 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 18% |
| Student > Doctoral Student | 6 | 15% |
| Student > Bachelor | 5 | 13% |
| Student > Ph. D. Student | 4 | 10% |
| Student > Master | 4 | 10% |
| Other | 7 | 18% |
| Unknown | 7 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 20% |
| Immunology and Microbiology | 8 | 20% |
| Biochemistry, Genetics and Molecular Biology | 6 | 15% |
| Medicine and Dentistry | 5 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
| Other | 3 | 8% |
| Unknown | 8 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 55. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2019.
All research outputs
#810,745
of 26,184,649 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#136
of 8,368 outputs
Outputs of similar age
#16,795
of 351,750 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#3
of 116 outputs
Altmetric has tracked 26,184,649 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,368 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 351,750 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 116 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.