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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Discovery of Benzopyrrolizidines as Promising Antigiardiasic Agents
|
|---|---|
| Published in |
Frontiers in Cellular and Infection Microbiology, January 2022
|
| DOI | 10.3389/fcimb.2021.828100 |
| Pubmed ID | |
| Authors |
Juan Carlos Auriostigue-Bautista, Eduardo Hernández-Vázquez, David González-Calderón, Jorge Luís Figueroa-Romero, Adriana Castillo-Villanueva, Angélica Torres-Arroyo, Martha Ponce-Macotela, Yadira Rufino-González, Mario Martínez-Gordillo, Luis D. Miranda, Jesús Oria-Hernández, Horacio Reyes-Vivas |
| Abstract |
Current treatments for giardiasis include drugs with undesirable side effects, which increase the levels of therapeutic desertion and promote drug resistance in the parasites. Herein, we describe the antigiardiasic evaluation on Giardia lamblia trophozoites of a structurally diverse collection of 74 molecules. Among these scaffolds, we discovered a benzopyrrolizidine derivative with higher antigiardiasic activity (IC50 = 11 µM) and lower cytotoxicity in human cell cultures (IC50 = 130 µM) than those displayed by the current gold-standard drugs (metronidazole and tinidazole). Furthermore, this compound produced morphologic modifications of trophozoites, with occasional loss of one of the nuclei, among other changes not observed with standard giardicidal drugs, suggesting that it might act through a novel mechanism of action. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 11 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 2 | 18% |
| Researcher | 2 | 18% |
| Student > Ph. D. Student | 1 | 9% |
| Professor | 1 | 9% |
| Student > Master | 1 | 9% |
| Other | 1 | 9% |
| Unknown | 3 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 2 | 18% |
| Biochemistry, Genetics and Molecular Biology | 2 | 18% |
| Veterinary Science and Veterinary Medicine | 1 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 9% |
| Social Sciences | 1 | 9% |
| Other | 1 | 9% |
| Unknown | 3 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2022.
All research outputs
#20,717,791
of 25,443,857 outputs
Outputs from Frontiers in Cellular and Infection Microbiology
#6,047
of 8,110 outputs
Outputs of similar age
#390,686
of 518,345 outputs
Outputs of similar age from Frontiers in Cellular and Infection Microbiology
#375
of 449 outputs
Altmetric has tracked 25,443,857 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,110 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 518,345 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 449 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.