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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Mechanisms and Consequences of Defective Efferocytosis in Atherosclerosis
|
|---|---|
| Published in |
Frontiers in Cardiovascular Medicine, January 2018
|
| DOI | 10.3389/fcvm.2017.00086 |
| Pubmed ID | |
| Authors |
Arif Yurdagul, Amanda C. Doran, Bishuang Cai, Gabrielle Fredman, Ira A. Tabas |
| Abstract |
Efficient clearance of apoptotic cells, termed efferocytosis, critically regulates normal homeostasis whereas defective uptake of apoptotic cells results in chronic and non-resolving inflammatory diseases, such as advanced atherosclerosis. Monocyte-derived macrophages recruited into developing atherosclerotic lesions initially display efficient efferocytosis and temper inflammatory responses, processes that restrict plaque progression. However, during the course of plaque development, macrophages undergo cellular reprogramming that reduces efferocytic capacity, which results in post-apoptotic necrosis of apoptotic cells and inflammation. Furthermore, defective efferocytosis in advanced atherosclerosis is a major driver of necrotic core formation, which can trigger plaque rupture and acute thrombotic cardiovascular events. In this review, we discuss the molecular and cellular mechanisms that regulate efferocytosis, how efferocytosis promotes the resolution of inflammation, and how defective efferocytosis leads to the formation of clinically dangerous atherosclerotic plaques. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 209 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 209 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 37 | 18% |
| Student > Ph. D. Student | 34 | 16% |
| Student > Master | 23 | 11% |
| Researcher | 19 | 9% |
| Student > Doctoral Student | 16 | 8% |
| Other | 20 | 10% |
| Unknown | 60 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 52 | 25% |
| Medicine and Dentistry | 25 | 12% |
| Immunology and Microbiology | 23 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 7% |
| Agricultural and Biological Sciences | 7 | 3% |
| Other | 21 | 10% |
| Unknown | 66 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2019.
All research outputs
#18,812,604
of 23,314,015 outputs
Outputs from Frontiers in Cardiovascular Medicine
#3,392
of 7,218 outputs
Outputs of similar age
#332,585
of 443,821 outputs
Outputs of similar age from Frontiers in Cardiovascular Medicine
#23
of 27 outputs
Altmetric has tracked 23,314,015 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,218 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 443,821 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.