Title |
Hypothalamic Obesity after Craniopharyngioma: Mechanisms, Diagnosis, and Treatment
|
---|---|
Published in |
Frontiers in endocrinology, January 2011
|
DOI | 10.3389/fendo.2011.00060 |
Pubmed ID | |
Authors |
Robert H. Lustig |
Abstract |
Obesity is a common complication after craniopharyngioma therapy, occurring in up to 75% of survivors. Its weight gain is unlike that of normal obesity, in that it occurs even with caloric restriction, and attempts at lifestyle modification are useless to prevent or treat the obesity. The pathogenesis of this condition involves the inability to transduce afferent hormonal signals of adiposity, in effect mimicking a state of CNS starvation. Efferent sympathetic activity drops, resulting in malaise and reduced energy expenditure, and vagal activity increases, resulting in increased insulin secretion and adipogenesis. Lifestyle intervention is essentially useless in this syndrome, termed "hypothalamic obesity." Pharmacologic treatment is also difficult, consisting of adrenergics to mimic sympathetic activity, or suppression of insulin secretion with octreotide, or both. Recently, bariatric surgery (Roux-en-Y gastric bypass, laparoscopic gastric banding, truncal vagotomy) have also been attempted with variable results. Early and intensive management is required to mitigate the obesity and its negative consequences. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 40% |
Canada | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 60% |
Practitioners (doctors, other healthcare professionals) | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 1% |
Unknown | 94 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 18 | 19% |
Student > Ph. D. Student | 13 | 14% |
Student > Bachelor | 10 | 11% |
Student > Master | 7 | 7% |
Student > Postgraduate | 6 | 6% |
Other | 13 | 14% |
Unknown | 28 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 39 | 41% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
Agricultural and Biological Sciences | 3 | 3% |
Biochemistry, Genetics and Molecular Biology | 3 | 3% |
Engineering | 3 | 3% |
Other | 11 | 12% |
Unknown | 32 | 34% |