Title |
Production of Hydrogen Sulfide from D-Cysteine and Its Therapeutic Potential
|
---|---|
Published in |
Frontiers in endocrinology, January 2013
|
DOI | 10.3389/fendo.2013.00087 |
Pubmed ID | |
Authors |
Norihiro Shibuya, Hideo Kimura |
Abstract |
Accumulating evidence shows that H2S has physiological functions in various tissues and organs. It includes regulation of neuronal activity, vascular tension, a release of insulin, and protection of the heart, kidney, and brain from ischemic insult. H2S is produced by enzymes from l-cysteine; cystathionine β-synthase, cystathionine γ-lyase, and 3-mercaptopyruvate sulfurtransferase (3MST) along with cysteine aminotransferase. We recently discovered an additional pathway for the production of H2S from d-cysteine. d-Amino acid oxidase provides 3-mercaptopyruvate for 3MST to produce H2S. d-Cysteine protects cerebellar neurons from oxidative stress and attenuates ischemia-reperfusion injury caused in the kidney more effectively than l-cysteine. This review focuses on a novel pathway for the production of H2S and its therapeutic application especially to the renal diseases. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Poland | 1 | 1% |
Unknown | 77 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 20 | 26% |
Researcher | 10 | 13% |
Student > Master | 9 | 12% |
Student > Bachelor | 6 | 8% |
Student > Doctoral Student | 4 | 5% |
Other | 10 | 13% |
Unknown | 19 | 24% |
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Agricultural and Biological Sciences | 19 | 24% |
Biochemistry, Genetics and Molecular Biology | 16 | 21% |
Medicine and Dentistry | 7 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
Chemistry | 4 | 5% |
Other | 5 | 6% |
Unknown | 22 | 28% |