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Molecular Mechanisms of Gonadotropin-Releasing Hormone Signaling: Integrating Cyclic Nucleotides into the Network

Overview of attention for article published in Frontiers in endocrinology, January 2013
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  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

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Title
Molecular Mechanisms of Gonadotropin-Releasing Hormone Signaling: Integrating Cyclic Nucleotides into the Network
Published in
Frontiers in endocrinology, January 2013
DOI 10.3389/fendo.2013.00180
Pubmed ID
Authors

Rebecca M. Perrett, Craig A. McArdle

Abstract

Gonadotropin-releasing hormone (GnRH) is the primary regulator of mammalian reproductive function in both males and females. It acts via G-protein coupled receptors on gonadotropes to stimulate synthesis and secretion of the gonadotropin hormones luteinizing hormone and follicle-stimulating hormone. These receptors couple primarily via G-proteins of the Gq/ll family, driving activation of phospholipases C and mediating GnRH effects on gonadotropin synthesis and secretion. There is also good evidence that GnRH causes activation of other heterotrimeric G-proteins (Gs and Gi) with consequent effects on cyclic AMP production, as well as for effects on the soluble and particulate guanylyl cyclases that generate cGMP. Here we provide an overview of these pathways. We emphasize mechanisms underpinning pulsatile hormone signaling and the possible interplay of GnRH and autocrine or paracrine regulatory mechanisms in control of cyclic nucleotide signaling.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 131 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 <1%
Turkey 1 <1%
United States 1 <1%
Denmark 1 <1%
Unknown 127 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 15%
Student > Bachelor 15 11%
Student > Master 12 9%
Researcher 11 8%
Professor > Associate Professor 9 7%
Other 32 24%
Unknown 32 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 32 24%
Biochemistry, Genetics and Molecular Biology 24 18%
Pharmacology, Toxicology and Pharmaceutical Science 12 9%
Medicine and Dentistry 7 5%
Neuroscience 6 5%
Other 12 9%
Unknown 38 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2014.
All research outputs
#16,747,916
of 25,411,814 outputs
Outputs from Frontiers in endocrinology
#4,392
of 13,058 outputs
Outputs of similar age
#187,935
of 289,120 outputs
Outputs of similar age from Frontiers in endocrinology
#75
of 210 outputs
Altmetric has tracked 25,411,814 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,058 research outputs from this source. They receive a mean Attention Score of 4.9. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,120 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 210 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.