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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Role of Pregnancy-Associated Hormones in the Development and Function of Regulatory B Cells
|
|---|---|
| Published in |
Frontiers in endocrinology, April 2014
|
| DOI | 10.3389/fendo.2014.00039 |
| Pubmed ID | |
| Authors |
Damián Muzzio, Marek Zygmunt, Federico Jensen |
| Abstract |
During mammalian pregnancy, highly specialized mechanisms of immune tolerance are triggered in order to allow the semi-allogeneic fetus to grow within the maternal uterus in harmony with the maternal immune system. Among other mechanisms, changes in the endocrine status have been proposed to be at least part of the machinery responsible for the induction of immune tolerance during pregnancy. Indeed, pregnancy-associated hormones, estradiol, progesterone, and human chorionic gonadotropin are known to confer immune suppressive capacity to innate as well as adaptive immune cells. Regulatory B cells, a subpopulation of B lymphocytes with strong immunosuppressive functions, were shown to expand during pregnancy. Furthermore, it is well-known that some women suffering from multiple sclerosis, significantly improve their symptoms during pregnancy and this was attributed to the effect of female sex hormones. Accordingly, estradiol protects mice from developing experimental autoimmune encephalomyelitis by triggering the expansion and activation of regulatory B cells. In this review, we discuss different mechanisms associated with the development, activation, and function of regulatory B cells with a special focus on those involving pregnancy-associated hormones. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| Belgium | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 92 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 18% |
| Student > Ph. D. Student | 14 | 15% |
| Student > Bachelor | 9 | 9% |
| Student > Master | 8 | 8% |
| Student > Doctoral Student | 6 | 6% |
| Other | 20 | 21% |
| Unknown | 21 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 23% |
| Agricultural and Biological Sciences | 20 | 21% |
| Immunology and Microbiology | 8 | 8% |
| Neuroscience | 5 | 5% |
| Biochemistry, Genetics and Molecular Biology | 3 | 3% |
| Other | 10 | 11% |
| Unknown | 27 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2014.
All research outputs
#19,944,091
of 25,373,627 outputs
Outputs from Frontiers in endocrinology
#5,754
of 13,012 outputs
Outputs of similar age
#167,274
of 239,202 outputs
Outputs of similar age from Frontiers in endocrinology
#32
of 48 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,012 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,202 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.