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Cardiac Autonomic Dysfunction in Type 2 Diabetes – Effect of Hyperglycemia and Disease Duration

Overview of attention for article published in Frontiers in endocrinology, August 2014
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Title
Cardiac Autonomic Dysfunction in Type 2 Diabetes – Effect of Hyperglycemia and Disease Duration
Published in
Frontiers in endocrinology, August 2014
DOI 10.3389/fendo.2014.00130
Pubmed ID
Authors

Mika P. Tarvainen, Tomi P. Laitinen, Jukka A. Lipponen, David J. Cornforth, Herbert F. Jelinek

Abstract

Heart rate variability (HRV) is reduced in diabetes mellitus (DM) patients, suggesting dysfunction of cardiac autonomic regulation and an increased risk for cardiac events. The aim of this paper was to examine the associations of blood glucose level (BGL), glycated hemoglobin (HbA1c), and duration of diabetes with cardiac autonomic regulation assessed by HRV analysis. Resting electrocardiogram (ECG), recorded over 20 min in supine position, and clinical measurements of 189 healthy controls and 93 type 2 DM (T2DM) patients were analyzed. HRV was assessed using several time-domain, frequency-domain, and non-linear methods. HRV parameters showed a clear difference between healthy controls and T2DM patients. Hyperglycemia was associated with increase in mean heart rate and decrease in HRV, indicated by negative correlations of BGL and HbA1c with mean RR interval and most of the HRV parameters. Duration of diabetes was strongly associated with decrease in HRV, the most significant decrease in HRV was found within the first 5-10 years of the disease. In conclusion, elevated blood glucose levels have an unfavorable effect on cardiac autonomic function and this effect is pronounced in long-term T2DM patients. The most significant decrease in HRV related to diabetes and thus presence of autonomic neuropathy was observed within the first 5-10 years of disease progression.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 1%
Colombia 1 1%
Unknown 89 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 18%
Student > Master 13 14%
Student > Bachelor 12 13%
Student > Postgraduate 9 10%
Researcher 8 9%
Other 15 16%
Unknown 18 20%
Readers by discipline Count As %
Medicine and Dentistry 29 32%
Engineering 10 11%
Agricultural and Biological Sciences 6 7%
Sports and Recreations 5 5%
Biochemistry, Genetics and Molecular Biology 3 3%
Other 15 16%
Unknown 23 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2014.
All research outputs
#17,235,172
of 25,373,627 outputs
Outputs from Frontiers in endocrinology
#5,125
of 13,009 outputs
Outputs of similar age
#143,806
of 242,059 outputs
Outputs of similar age from Frontiers in endocrinology
#30
of 46 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 31st percentile – i.e., 31% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,009 research outputs from this source. They receive a mean Attention Score of 4.9. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,059 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.