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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Ghrelin-Derived Peptides: A Link between Appetite/Reward, GH Axis, and Psychiatric Disorders?
|
|---|---|
| Published in |
Frontiers in endocrinology, October 2014
|
| DOI | 10.3389/fendo.2014.00163 |
| Pubmed ID | |
| Authors |
Alexandra Labarthe, Oriane Fiquet, Rim Hassouna, Philippe Zizzari, Laurence Lanfumey, Nicolas Ramoz, Dominique Grouselle, Jacques Epelbaum, Virginie Tolle |
| Abstract |
Psychiatric disorders are often associated with metabolic and hormonal alterations, including obesity, diabetes, metabolic syndrome as well as modifications in several biological rhythms including appetite, stress, sleep-wake cycles, and secretion of their corresponding endocrine regulators. Among the gastrointestinal hormones that regulate appetite and adapt the metabolism in response to nutritional, hedonic, and emotional dysfunctions, at the interface between endocrine, metabolic, and psychiatric disorders, ghrelin plays a unique role as the only one increasing appetite. The secretion of ghrelin is altered in several psychiatric disorders (anorexia, schizophrenia) as well as in metabolic disorders (obesity) and in animal models in response to emotional triggers (psychological stress …) but the relationship between these modifications and the physiopathology of psychiatric disorders remains unclear. Recently, a large literature showed that this key metabolic/endocrine regulator is involved in stress and reward-oriented behaviors and regulates anxiety and mood. In addition, preproghrelin is a complex prohormone but the roles of the other ghrelin-derived peptides, thought to act as functional ghrelin antagonists, are largely unknown. Altered ghrelin secretion and/or signaling in psychiatric diseases are thought to participate in altered appetite, hedonic response and reward. Whether this can contribute to the mechanism responsible for the development of the disease or can help to minimize some symptoms associated with these psychiatric disorders is discussed in the present review. We will thus describe (1) the biological actions of ghrelin and ghrelin-derived peptides on food and drugs reward, anxiety and depression, and the physiological consequences of ghrelin invalidation on these parameters, (2) how ghrelin and ghrelin-derived peptides are regulated in animal models of psychiatric diseases and in human psychiatric disorders in relation with the GH axis. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 165 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Germany | 1 | <1% |
| Argentina | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 161 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 27 | 16% |
| Student > Ph. D. Student | 26 | 16% |
| Student > Bachelor | 20 | 12% |
| Researcher | 17 | 10% |
| Student > Doctoral Student | 9 | 5% |
| Other | 28 | 17% |
| Unknown | 38 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 33 | 20% |
| Psychology | 22 | 13% |
| Neuroscience | 20 | 12% |
| Agricultural and Biological Sciences | 17 | 10% |
| Nursing and Health Professions | 6 | 4% |
| Other | 20 | 12% |
| Unknown | 47 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2023.
All research outputs
#14,776,743
of 25,654,806 outputs
Outputs from Frontiers in endocrinology
#3,004
of 13,262 outputs
Outputs of similar age
#131,220
of 274,255 outputs
Outputs of similar age from Frontiers in endocrinology
#17
of 62 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,262 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,255 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.