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Role of Protein Kinase C in Podocytes and Development of Glomerular Damage in Diabetic Nephropathy

Overview of attention for article published in Frontiers in endocrinology, November 2014
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Title
Role of Protein Kinase C in Podocytes and Development of Glomerular Damage in Diabetic Nephropathy
Published in
Frontiers in endocrinology, November 2014
DOI 10.3389/fendo.2014.00179
Pubmed ID
Authors

Beina Teng, Michelle Duong, Irini Tossidou, Xuejiao Yu, Mario Schiffer

Abstract

The early glomerular changes in diabetes include a podocyte phenotype with loss of slit diaphragm proteins, changes in the actin cytoskeleton and foot process architecture. This review focuses on the role of the protein kinase C (PKC) family in podocytes and points out the differential roles of classical, novel, and atypical PKCs in podocytes. Some PKC isoforms are indispensable for proper glomerular development and slit diaphragm maintenance, whereas others might be harmful when activated in the diabetic milieu. Therefore, some might be interesting treatment targets in the early phase of diabetes.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
United States 1 2%
Unknown 44 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 28%
Student > Bachelor 7 15%
Student > Ph. D. Student 5 11%
Researcher 4 9%
Student > Doctoral Student 4 9%
Other 5 11%
Unknown 8 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 13 28%
Medicine and Dentistry 10 22%
Agricultural and Biological Sciences 6 13%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Immunology and Microbiology 2 4%
Other 3 7%
Unknown 10 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2014.
All research outputs
#20,657,128
of 25,374,917 outputs
Outputs from Frontiers in endocrinology
#6,734
of 13,013 outputs
Outputs of similar age
#202,416
of 276,338 outputs
Outputs of similar age from Frontiers in endocrinology
#43
of 70 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,013 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,338 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.