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Hypothalamic–Pituitary–Gonadal Axis Involvement in Learning and Memory and Alzheimer’s Disease: More than “Just” Estrogen

Overview of attention for article published in Frontiers in endocrinology, March 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

news
1 news outlet
twitter
2 X users

Citations

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41 Dimensions

Readers on

mendeley
86 Mendeley
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Title
Hypothalamic–Pituitary–Gonadal Axis Involvement in Learning and Memory and Alzheimer’s Disease: More than “Just” Estrogen
Published in
Frontiers in endocrinology, March 2015
DOI 10.3389/fendo.2015.00045
Pubmed ID
Authors

Jeffrey A. Blair, Henry McGee, Sabina Bhatta, Russell Palm, Gemma Casadesus

Abstract

Accumulating studies affirm the effects of age-related endocrine dysfunction on cognitive decline and increasing risk of neurodegenerative diseases. It is well known that estrogens can be protective for cognitive function, and more recently androgens and luteinizing hormone have also been shown to modulate learning and memory. Understanding the mechanisms underlying hypothalamic-pituitary-gonadal axis-associated cognitive dysfunction is crucial for therapeutic advancement. Here, we emphasize that reproductive hormones are influential in maintaining neuronal health and enhancing signaling cascades that lead to cognitive impairment. We summarize and critically evaluate age-related changes in the endocrine system, their implications in the development of Alzheimer's disease, and the therapeutic potential of endocrine modulation in the prevention of age-related cognitive decline.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 85 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 15 17%
Student > Master 13 15%
Student > Ph. D. Student 12 14%
Researcher 7 8%
Student > Doctoral Student 6 7%
Other 12 14%
Unknown 21 24%
Readers by discipline Count As %
Medicine and Dentistry 17 20%
Biochemistry, Genetics and Molecular Biology 10 12%
Psychology 8 9%
Neuroscience 8 9%
Agricultural and Biological Sciences 7 8%
Other 10 12%
Unknown 26 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2015.
All research outputs
#3,707,436
of 26,150,873 outputs
Outputs from Frontiers in endocrinology
#1,129
of 13,366 outputs
Outputs of similar age
#44,727
of 279,280 outputs
Outputs of similar age from Frontiers in endocrinology
#6
of 57 outputs
Altmetric has tracked 26,150,873 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,366 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,280 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.