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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Short-Chain Fatty Acids Differentially Affect Intracellular Lipolysis in a Human White Adipocyte Model
|
|---|---|
| Published in |
Frontiers in endocrinology, January 2018
|
| DOI | 10.3389/fendo.2017.00372 |
| Pubmed ID | |
| Authors |
Johan W. E. Jocken, Manuel A. González Hernández, Nicole T. H. Hoebers, Christina M. van der Beek, Yvonne P. G. Essers, Ellen E. Blaak, Emanuel E. Canfora |
| Abstract |
Gut-derived short-chain fatty acids (SCFA), formed by microbial fermentation of dietary fibers, are believed to be involved in the etiology of obesity and diabetes. Previous data from our group showed that colonic infusions of physiologically relevant SCFA mixtures attenuated whole-body lipolysis in overweight men. To further study potential mechanisms involved in the antilipolytic properties of SCFA, we aimed to investigate the in vitro effects of SCFA incubations on intracellular lipolysis and signaling using a human white adipocyte model, the human multipotent adipose tissue-derived stem (hMADS) cells. hMADS adipocytes were incubated with mixtures of acetate, propionate, and butyrate or single SCFA (acetate, propionate and butyrate) in concentrations ranging between 1 µmol/L and 1 mmol/L. Glycerol release and lipase activation was investigated during basal conditions and following β-adrenergic stimulation. SCFA mixtures high in acetate and propionate decreased basal glycerol release, when compared to control (P < 0.05), while mixtures high in butyrate had no effect. Also, β-adrenergic receptor mediated glycerol release was not significantly altered following incubation with SCFA mixtures. Incubation with only acetate decreased basal (1 µmol/L) and β-adrenergically (1 µmol/L and 1 mmol/L) mediated glycerol release when compared with control (P < 0.05). In contrast, butyrate (1 µmol/L) slightly increased basal and β-adrenergically mediated glycerol release compared with control (P < 0.05), while propionate had no effect on lipolysis. The antilipolytic effect of acetate was accompanied by a reduced phosphorylation of hormone-sensitive lipase (HSL) at serine residue 650. In addition, inhibition of Gi G proteins following pertussis toxin treatment prevented the antilipolytic effect of acetate. The present data demonstrated that acetate was mainly responsible for the antilipolytic effects of SCFA and acts via attenuation of HSL phosphorylation in a Gi-coupled manner in hMADS adipocytes. Therefore, the modulation of colonic and circulating acetate may be an important target to modulate human adipose tissue lipid metabolism. |
X Demographics
The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 11% |
| United States | 2 | 7% |
| Canada | 2 | 7% |
| United Arab Emirates | 1 | 4% |
| Sweden | 1 | 4% |
| Mexico | 1 | 4% |
| Italy | 1 | 4% |
| Ireland | 1 | 4% |
| Denmark | 1 | 4% |
| Other | 2 | 7% |
| Unknown | 13 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 50% |
| Scientists | 8 | 29% |
| Practitioners (doctors, other healthcare professionals) | 4 | 14% |
| Science communicators (journalists, bloggers, editors) | 2 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 94 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 16% |
| Student > Ph. D. Student | 12 | 13% |
| Student > Bachelor | 8 | 9% |
| Other | 7 | 7% |
| Student > Doctoral Student | 5 | 5% |
| Other | 17 | 18% |
| Unknown | 30 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 13% |
| Agricultural and Biological Sciences | 11 | 12% |
| Biochemistry, Genetics and Molecular Biology | 11 | 12% |
| Nursing and Health Professions | 5 | 5% |
| Immunology and Microbiology | 3 | 3% |
| Other | 14 | 15% |
| Unknown | 38 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2024.
All research outputs
#1,797,825
of 26,156,431 outputs
Outputs from Frontiers in endocrinology
#471
of 13,367 outputs
Outputs of similar age
#39,755
of 456,400 outputs
Outputs of similar age from Frontiers in endocrinology
#6
of 103 outputs
Altmetric has tracked 26,156,431 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,367 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 456,400 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 103 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.