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Oncocytic Adrenocortical Neoplasm with Concomitant Papillary Thyroid Cancer

Overview of attention for article published in Frontiers in endocrinology, January 2018
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Title
Oncocytic Adrenocortical Neoplasm with Concomitant Papillary Thyroid Cancer
Published in
Frontiers in endocrinology, January 2018
DOI 10.3389/fendo.2017.00384
Pubmed ID
Authors

Michele Podetta, Marc Pusztaszeri, Christian Toso, Michel Procopiou, Frédéric Triponez, Samira Mercedes Sadowski

Abstract

Adrenal oncocytoma (AO) is an extremely rare adrenocortical neoplasm and little is known about its malignant potential, secretory properties, and hereditary origin. We present the case of a benign AO with concomitant incidentally found papillary thyroid cancer (PTC) and review similar cases in the literature. Immunohistochemistry and next-generation sequencing (NGS) were performed. A 66-year-old women was incidentally found to have a large, androgen-secreting right adrenal mass. 18F-Fluorodeoxyglucose positron emission tomography showed intense uptake (SUVmax 88.7) of this mass and found a hypermetabolic right thyroid mass. Open adrenalectomy was performed for this highly suspicious adrenal mass. Histopathology revealed benign AO that was BRAFV600E negative, with low Ki-67, and no somatic mutation found on NGS. Thyroidectomy revealed invasive, BRAFV600E-positive PTC. At 6 months follow-up, androgen levels returned to normal, and no recurrence was seen on imaging. To our knowledge, this is the first report of an androgen-secreting AO with concomitant PTC. Possibly the simultaneous discovery of two independent neoplasms was observed. In conclusion, this case highlights that care should be given to exclude concomitant neoplasms. Long-term and regular imaging with biochemical follow-up is warranted, since the outcome and clinical behavior of AO remains uncertain.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Other 3 21%
Student > Master 3 21%
Student > Bachelor 2 14%
Professor 1 7%
Student > Ph. D. Student 1 7%
Other 1 7%
Unknown 3 21%
Readers by discipline Count As %
Medicine and Dentistry 5 36%
Biochemistry, Genetics and Molecular Biology 2 14%
Computer Science 1 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Earth and Planetary Sciences 1 7%
Other 1 7%
Unknown 3 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 January 2018.
All research outputs
#23,730,072
of 26,414,132 outputs
Outputs from Frontiers in endocrinology
#9,197
of 13,537 outputs
Outputs of similar age
#397,545
of 456,493 outputs
Outputs of similar age from Frontiers in endocrinology
#71
of 115 outputs
Altmetric has tracked 26,414,132 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,537 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 115 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.