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Physiological and Molecular Mechanisms of Methionine Restriction

Overview of attention for article published in Frontiers in endocrinology, May 2018
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Title
Physiological and Molecular Mechanisms of Methionine Restriction
Published in
Frontiers in endocrinology, May 2018
DOI 10.3389/fendo.2018.00217
Pubmed ID
Authors

Mary Neslund Latimer, Khalid Walid Freij, Beth M. Cleveland, Peggy R. Biga

Abstract

Methionine restriction (MR) has been studied extensively over the last 25 years for its role in altering metabolic hallmarks of disease. Animals subjected to MR, display changes in metabolic flexibility demonstrated by increases in energy expenditure, glucose tolerance, and lifespan. These changes have been well characterized in a number of model systems and significant progress has been made in understanding how hepatic fibroblast growth factor 21 links MR to several components of its metabolic phenotype. Despite these advances, a complete understanding of mechanisms engaged by dietary MR remains elusive. In this review, we offer a brief history of MR and its known mechanisms associated with stress, metabolism, and lifespan extension. We consider the role of epigenetics in the response of animals to MR and propose a novel epigenetic pathway involving the regulation of microRNAs during MR.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 49 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 22%
Student > Ph. D. Student 7 14%
Student > Master 6 12%
Researcher 6 12%
Student > Doctoral Student 4 8%
Other 10 20%
Unknown 5 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 18 37%
Agricultural and Biological Sciences 10 20%
Medicine and Dentistry 4 8%
Nursing and Health Professions 2 4%
Unspecified 2 4%
Other 8 16%
Unknown 5 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2018.
All research outputs
#22,767,715
of 25,382,440 outputs
Outputs from Frontiers in endocrinology
#8,340
of 13,021 outputs
Outputs of similar age
#299,426
of 339,789 outputs
Outputs of similar age from Frontiers in endocrinology
#170
of 219 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,021 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 219 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.